CD3e CD3ε, Part of CD3 family, T3
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Type 1 glycoprotein
T Cell
20 / 20

Expression
CD3e is expressed during thymopoiesis and on mature T cells in periphery.

Structure
MOLECULAR FAMILY NAME:  Belongs to the immunoglobulin supergene family.

CD3ε is a single-pass type-1 glycoprotein.  It contains an extracellular domain which contains no glycoslation sites, a 26 aa transmembrane domain and a 26-27 aa cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).  The stoichiometry of a CD3 complex is not established but is generally thought to contain 2 CD3e chains. 

MOLECULAR MASS
Cell Type Unreduced Reduced
20 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION
: No information.



Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD3e

CD3ε interacts with peptide bound to MHC molecules.


Function
Recognition of antigen leads to signal transduction and subsequently T cell activation.  Knockout mice show no development of T cells.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD3e IN INTACT ANIMAL

A defect in CD3ε causes an severe combined immunodeficiency (SCID).


Comments
MOLECULAR INTERACTIONS-
PROTEIN AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD3e: No information.

SUBSTRATES
: No information.

ENZYMES WHICH MODIFY CD3
e: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 916P07766
Antibodies
CD3-12   View Reactivity

Revised June 25, 2008


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