|CD3e||CD3ε, Part of CD3 family, T3|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
Type 1 glycoprotein
|T Cell||20 / 20|
|CD3e is expressed during thymopoiesis and on mature T cells in periphery.|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.|
CD3ε is a single-pass type-1 glycoprotein. It contains an extracellular domain which contains no glycoslation sites, a 26 aa transmembrane domain and a 26-27 aa cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). The stoichiometry of a CD3 complex is not established but is generally thought to contain 2 CD3e chains.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD3e|
CD3ε interacts with peptide bound to MHC molecules.
|Recognition of antigen leads to signal transduction and subsequently T cell activation. Knockout mice show no development of T cells.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD3e IN INTACT ANIMAL
A defect in CD3ε causes an severe combined immunodeficiency (SCID).
PROTEIN AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD3e: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD3e: No information.
Database accession numbers
Revised June 25, 2008