CD3g CD3γ, Part of CD3 family, T3
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Type 1 glycoprotein
T Cell
25 / 25

Expression
CD3g is expressed during thymopoiesis and on mature T cells in the periphery.  Less than 10% of human peripheral T cells express the g/d TCR complex but in the mouse the great majority of T cells present on some epithelial tissues are g/d + and have limited receptor diversity.

Structure
MOLECULAR FAMILY NAME:  Belongs to the immunoglobulin supergene family.

CD3γ is a single-pass type-1 glycoprotein.  It contains an extracellular domain which contains 2 glycosylation sites, a 26-27 aa transmembrane domain and a cytoplasmic domain containing an immunoreceptor tyrosine-based activation motif (ITAM).  The di-leucine motif is important for internatization of the CD3-TCR complex in activated T cells.  The stoichiometry of a CD3/TCR complex is not established but is generally thought to contain 1 CD3g chain.  The g/d heterodimers are clonotypic and consist of Ig-like variable and constant domains.

MOLECULAR MASS
Cell Type Unreduced Reduced
25-28 kDa

POST-TRANSCRIPTIONAL MODIFICATION
: No information.

POST-TRANSLATIONAL MODIFICATION
: No information.



Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD3γ

The antigen interacts with peptide bound to MHC molecules.




Function
Recognition of CD3γ leads to signal transduction and subsequently T cell activation.

BIOCHEMICAL ACTIVITY
: No information.

DISEASE RELEVANCE AND FUNCTION OF CD3g IN INTACT ANIMAL

CD3g defects are associated with T cell immunodeficiency.


Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD3g: No information.

SUBSTRATES
: No information.

ENZYMES WHICH MODIFY CD3
g: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 917P09693
Antibodies

Revised June 25, 2008


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