|CD3g||CD3γ, Part of CD3 family, T3|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
Type 1 glycoprotein
|T Cell||25 / 25|
|CD3g is expressed during thymopoiesis and on mature T cells in the periphery. Less than 10% of human peripheral T cells express the g/d TCR complex but in the mouse the great majority of T cells present on some epithelial tissues are g/d + and have limited receptor diversity.|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.|
CD3γ is a single-pass type-1 glycoprotein. It contains an extracellular domain which contains 2 glycosylation sites, a 26-27 aa transmembrane domain and a cytoplasmic domain containing an immunoreceptor tyrosine-based activation motif (ITAM). The di-leucine motif is important for internatization of the CD3-TCR complex in activated T cells. The stoichiometry of a CD3/TCR complex is not established but is generally thought to contain 1 CD3g chain. The g/d heterodimers are clonotypic and consist of Ig-like variable and constant domains.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD3γ|
The antigen interacts with peptide bound to MHC molecules.
|Recognition of CD3γ leads to signal transduction and subsequently T cell activation.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD3g IN INTACT ANIMAL
CD3g defects are associated with T cell immunodeficiency.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD3g: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD3g: No information.
Database accession numbers
Revised June 25, 2008