|CD175||TN antigen (T-antigen novelle)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
|CD175 is expressed on various carcinomas at varying frequencies, histo-blood group-related carbohydrate antigens and a precursors of the blood groups ABO and TF antigen. It is expressed on cell lines of different CD34+ hematopoietic progenitor cells and lineages such as lines derived from acute myelogenous leukemia, erythroblastic cell leukemia, B cell leukemia, T cell leukemia and epithelial tumors. CD175 is expressed in all hematopoietic cell arising from the progenitors in Tn syndrome. The expression is restricted to 2 erythroblastic cell lines. CD175 is also expressed on epithelial cells, hematopoietic bone marrow cells, myeloid lineage, breast, ovary, colorectal, gastrointestinal, bladder, larynx and lung carconoma cells. |
|MOLECULAR FAMILY NAME: Belongs to the carbohydrate chain. |
CD175 is a tumor-specific antigen. It consists of monosaccharide GalNAca1-O-R expressed on glycosphingolipids or O-linked to proteins. It is precursor molecule for several blood groups, ABO system and the TF antigen. Sialyl-CD175 is synthesized by ST6GalNAc1, which catalyses the transfer of the sialic acid residue in the α2,6 linkage to the CD175 structure. The resulting disaccharide cannot be further elongated.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
| LIGANDS AND MOLECULES ASSOCIATED WITH CD175: No information.|
|CD175 is the precursor for ABO antigens and the Thomsen-Friedenreich antigen, CD176. It is a tumor-associated carbohydrate antigen that arises from aberrant O-linked glycosylation and is not found on differentiation cells. Cytotoxic CD8+ T cells are capable of recognizing CD175 and CD175s in a MHC class I restricted manner.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD175 IN INTACT ANIMAL
CD175 is a vaccine candidate in the prevention and treatment of mucin expressing tumors. A specific mAb has been used for prognosis and therapeutic applications. A rare Tn sydrome, CD175, is expressed by a proportion of CD34+ hematopoietic stem cells and their progeny due to the absence of UDO-Gal:N-acetylgalactosaminideβ1-3galactosyltransferase activity. Most patients appear healthy but usually have moderate thrombocytopenia and leukopenia and some indicators of hemolytic anemia.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD175: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD175: No information.
Database accession numbers
Revised June 25, 2008