CD175 TN antigen (T-antigen novelle)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Carbohydrate
Ovary
Lung
Epithelial Cell
Myeloid Cell
Hematopoietic Cell
Bone Marrow
B Cell
Gastrointestine
T Cell
Leukemia cell
Colon
Bladder
Larynx

Expression
CD175 is expressed on various carcinomas at varying frequencies, histo-blood group-related carbohydrate antigens and a precursors of the blood groups ABO and TF antigen.  It is expressed on cell lines of different CD34+ hematopoietic progenitor cells and lineages such as lines derived from acute myelogenous leukemia, erythroblastic cell leukemia, B cell leukemia, T cell leukemia and epithelial tumors.   CD175 is expressed in all hematopoietic cell arising from the progenitors in Tn syndrome. The expression is restricted to 2 erythroblastic cell lines.  CD175 is also expressed on epithelial cells, hematopoietic bone marrow cells, myeloid lineage, breast, ovary, colorectal, gastrointestinal, bladder, larynx and lung carconoma cells. 

Structure
MOLECULAR FAMILY NAME:  Belongs to the carbohydrate chain. 

CD175 is a tumor-specific antigen.  It consists of monosaccharide GalNAca1-O-R expressed on glycosphingolipids or O-linked to proteins.  It is precursor molecule for several blood groups, ABO system and the TF antigen.  Sialyl-CD175 is synthesized by ST6GalNAc1, which catalyses the transfer of the sialic acid residue in the ╬▒2,6 linkage to the CD175 structure.  The resulting disaccharide cannot be further elongated.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD175: No information.

Function
CD175 is the precursor for ABO antigens and the Thomsen-Friedenreich antigen, CD176.  It is a tumor-associated carbohydrate antigen that arises from aberrant O-linked glycosylation and is not found on differentiation cells.  Cytotoxic CD8+ T cells are capable of recognizing CD175 and CD175s in a MHC class I restricted manner.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD175 IN INTACT ANIMAL

CD175 is a vaccine candidate in the prevention and treatment of mucin expressing tumors.  A specific mAb has been used for prognosis and therapeutic applications.  A rare Tn sydrome, CD175, is expressed by a proportion of CD34+ hematopoietic stem cells and their progeny due to the absence of UDO-Gal:N-acetylgalactosaminide╬▓1-3galactosyltransferase activity.  Most patients appear healthy but usually have moderate thrombocytopenia and leukopenia and some indicators of hemolytic anemia.

Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD175: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD175: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


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