CD175s Sialyl-Tn
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Carbohydrate
Erythroblast
Lung
Epithelial Cell
Endothelial Cell
Ovary
Breast
Colon
Gastrointestine
Bladder
Larynx

Expression
CD175s is expressed on endothelial and epithelial cells and erythroblasts.  It is expressed by breast, ovary, colorectal, gastrointestinal, bladder, larynx and lung carinoma cells.

Structure
MOLECULAR FAMILY NAME:  Belongs to the carbohydrate chain.

CD175s is the sialylated epitope on O-linked monosaccharide GalNAcĪ±1-O-R, expressed on glycosphingolipid or glycoprotein. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD175s: No information.

Function
CD175s has shown binding to CD22, Siglec-3-5 and 6. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD175s IN INTACT ANIMAL

CD175 has been implicated in the induction of metastasis and invasiveness of tumors.  It is overexpressed in several carcinomas and is associated with poor prognosis.  CD175s is a vaccine candidate for colorectal and non-small cell lung cancer.CD175s conjugated to keyhole limpet hemocyanin (Theratope) is being trialed as a vaccine for colorectal and non-small cell lung cancer.  A large scale phase III clinical trial of Theratope in breast cancer patients was completed in 2003 and it is currently neing assessed in patients with metastatic breast cancer.  Transfection of CD175s-ve breast cancer cell lines with ST6GalNAc1 cDNA results in expression of CD175s and decreased adhesion and increased migration of cells.

Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD175s: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD175s: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


Contact us: Webmaster |  509-335-9515 | Accessibility | Copyright | Policies
College of Veterinary Medicine Washington State University, Pullman, WA, 99164-7010 USA
Copyright 1995-2003 Washington State University