|CD180||LY64 (lymphocyte antigen 64 homolog), RP105, Bgp95|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|95 / 95|
100 / 100
|CD180 is strongly expressed on mantle, marginal zone and peripherical B cells, but is weakly or negatively expressed on germinal center B cells and not detected in pre-B and T cells. It is also expressed on peripheral blood monocytes, dendritic cells and on the plasma membrane. In the mouse expression is mainly on mature IgM+ and IgD+ B cells. Expression is also detected in spleen, lymph node and appendix.|
|MOLECULAR FAMILY NAME: Belongs to the Toll-like receptor family.|
CD180 is a single-pass type-1 661 aa glycoprotein. It contains a putative signal sequence, an extracellular domain which contains 17 leucine-rich repeats (LRR) that consist of 24-28 aa tandem repeats of a leucine-rich motif (LRM) in which leucines are characteristically positioned, a transmembrane domain and a short cytoplasmic domain which contains a 11 aa sequence and includes 2 tyrosine residues. The extracellular repeats are associated with a molecule called MD-1 and forms the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a constituent of Gram-negative bacteria. Some proteins that contain LRR molecules are used for pathogen recognition in organisms as divergent as plants, flies, mice and humans.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD180
|CD180 regulates LPS recognition and signaling and B cell activation. Ligation of CD180 on murine B cells like CD40 ligation by a mAb induces activation that leads to upregulation of co-stimulatory molecules, CD80 and CD86 and an increase in cell size. CD180 stimulation makes B cells more susceptible to BCR induced cell death but not to CD95 induced apoptosis. Ligating CD40 has the opposite effect rendering B cells more susceptible to CD95 mediated death. Ligating CD180 on human B cells alone can induce B cells to enter G1 phase of the cell cycle and then proliferate. CD180 may play a role in the transmission of a growth-promoting signal. CD180 leads to NF-κB activation and is involved in the life/death decision of B cells. B cells from null mice lacking CD180 are impaired in LPS-induced proliferation and antibody production. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD180 IN INTACT ANIMAL
Decreased expression of CD180 has been shown in systemic lupus erythematosus (SLE). The loss of CD180 is associated with B cell activation and increased disease activity in SLE patients.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD180: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD180: No information.
Database accession numbers
Revised June 25, 2008