CD225 IFITM1 (interferon induced transmembrane protein 1), LEU13
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 3 glycoprotein, 2 span
T Cell
Endothelial Cell
Leukocyte
Lymph Node
Thymus
Peripheral blood
Leukemia cell
17 / 17

Expression
CD225 is expressed on leukocytes, endothelial cells and in multiple lineages.  Expression occurs at high levels on human T cells in peripheral blood, thymus and the paracortical region of lymph nodes.  It is expressed on circulating normal and malignant B cells from patients with chronic lymphocytic leukemia (CLL), prolymphocytic leukemia (PLL) and hairy cell leukemia (HCL), but the density is lower than on T lymphocytes.  CD225 is expressed late during B cell maturation following expression of CD19 and CD81.  Expression on follicular B cells in lymph nodes is low to non-detectable.  It is not expressed on monocytes, neutrophils, vascular endothelial cells or vacular endothelium in organs.  CD225 is expressed on the external face of plasma membrane.

Structure
MOLECULAR FAMILY NAME: Belongs to the interferon-induced protein family.

CD225 is a multi-pass type-3 2 span 125 aa glycoprotein.  It contains an extracellular domain, 2 transmembrane domains containing a C-terminus with a hydrophobic region but the struture of the molecule is not well characterized and a cytoplasmic domain.  CD225 contains a partial conserved 'leucine zipper' motif, 2 potenial protein kinase C and 1 potential casein kinase 2 substrate motifs.  CD225 coprecipitates with TAPA-1.

MOLECULAR MASS
Cell Type Unreduced Reduced
17 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD225

CD225 associates with complexes of CD81, CD19 and CD21.

Function
The specific role of CD225 is not clear but it is a component of the CD21/CD19/TATA-1 complex.  CD225 is a pan endothelial cell marker and an interferon induced transmembrane protein that may play a role in controlling cell to cell interactions.  It is implicated in the involvement of B cell activation, in cell growth and is a component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals.  CD225 is non-covalently associated with the tetraspan molecule CD81, TAPA-1 in cells of multiple lineages.  These molecules are broadly expressed members of a signal transduction complex which includes lineage-specific proteins.  It is not clear whether CD225 can independently transduce cellular signals or if it requires CD81 and associated molecules for biological responses.  Despite the prominent expression of CD225 on blood vessels, the biological function of the signal transduction molecule in vascular endothelial cells is unknown.  CD225 is involved in lymphocyte activation and development.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD225 IN INTACT ANIMAL: No information.


Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD225: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD225: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 8519P13164
Antibodies

Revised June 25, 2008


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