CD232 PLXNC1(plexin C1), VESPR (Virally encoded semaphorin receptor),
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Myeloid Cell
B Cell
Monocyte
Granulocyte
NK Cell
Heart
Lung
Spleen
Brain
Placenta
Dendritic Cell
Neuron
B Lymphocyte
200 / 200

Expression
CD232 is expressed in a variety cell types including myeloid cells and B lymphocytes.  Expression is on B cells, NK cells, dendritic cells, neuronal cells, monocytes and granulocytes.  Expression is also found in the heart, brain, lung, spleen, and placenta.   

Structure
MOLECULAR FAMILY NAME: Belongs to the  plexin family.

CD232 is a single-pass type-1 1568 aa transmembrane glycoprotein.  It contains an extracellular domain which contains short cysteine-rich motifs, glycine- and proline-rich motifs and a semphorin domain, a transmembrane domain and a cytoplasmic domain.  CD232 was identified with a cDNA encoding a neuronal cell surface marker in Xenopus.  There are 3 more plexins that have been identified in the mouse brain.

MOLECULAR MASS
Cell Type Unreduced Reduced
200 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

CD232 is N glycosylated.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD232

CD232 associates with CD108(semaphorin 7A) and the poxvirus semaphorin-like protein A39R.

Function
The function of CD232 is unclear but is thought to be a receptor for virally encoded semaphorin (A39R) and semaphorin 7A.  CD232 binds a semaphorin derived from a virus with no known neuronal phase which strongly suggests that at least some plexins are likely to play a role in immune modulation.  Binding of the viral semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL-6 and IL-8.  A39R has been shown to transmit a signal through CD232 that results in biological activity in monocytes, some classes of dendritic cells, neutrophils and B lymphocytes.  A39R upregulates ICAM-1 and induces cytokine production.  A39R ligation of murine CD232 inhibits integrin-mediated dendritic cell adhesion and chemokine-induced migration in vitro.  CD232-/- mice display normal dendritic cell development and normal T-cell responses in vitro.  However, in vivo migration of the dendritic cells to lymph nodes and T cell responses were somewhat reduced compared with wild-type dendritic cells.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD232 IN INTACT ANIMAL

CD232 is a receptor for CD108 and a semaphorin from virus.  CD232 functions as a high affinity receptor for a poxvirus encoded vaccinia virus semaphorin termed A39R and for herpesvirus sema protein.  CD232 upregulated ICAM1 on, and induced cytokine production from, human monocytes, suggesting that this protein can function as an immune modulator during virus infection.


Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD232: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD232: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene10154O60486
Antibodies

Revised June 25, 2008


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