KLRF1 

KLRF1 (killer cell lectin-like receptor subfamily F, member 1)

Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
Peripheral blood
Leukocyte
Spleen
NK Cell
Monocyte

Expression

KLRF1 is strongly expression in peripheral blood leukocytes and spleen.  Within the peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes.   Expression is weak in lymph node and adult liver and no expression in bone marrow, thymus, fetal liver, brain, heart, placenta, lung, kidney, skeletal muscle and pancreas.



Structure
MOLECULAR FAMILY NAME: Belongs to the killer cell lectin-like superfamily.

KLRF1 is a single-pass type-2 231 aa glycoprotein.  It contains an 166 aa extracellular domain which contains a Ig-like C-type lectin domain with 6 invariant cys residues, a 23 aa transmembrane domain and a 42 aa cytoplasmic domain which contains 2 ITIM motifs.

MOLECULAR MASS: No information.

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 4 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH KLRF1: No information.

Function
NK lectin-like receptors like KLRF1 may contain a ITIM motif.  Upon MHC class I engagement and tyrosine phosphorylation of the ITIM, SHP1 is recruited to the ITIM and an inhibitory signal cascade which leads to the abrogation of NK cell activation.  KLFR1 is involved in the natural killer-mediated cytolysis of PHA-induced lymphoblasts.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF KLFR1 IN INTACT ANIMAL: No information.


Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF KLFR1: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY KLFR1: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene51348Q9NZS2
Antibodies

Revised June 25, 2008


Contact us: Webmaster |  509-335-9515 | Accessibility | Copyright | Policies
College of Veterinary Medicine Washington State University, Pullman, WA, 99164-7010 USA
Copyright 1995-2003 Washington State University