KLRF1 (killer cell lectin-like receptor subfamily F, member 1)
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 2 glycoprotein
KLRF1 is strongly expression in peripheral blood leukocytes and spleen. Within the peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes. Expression is weak in lymph node and adult liver and no expression in bone marrow, thymus, fetal liver, brain, heart, placenta, lung, kidney, skeletal muscle and pancreas.
|MOLECULAR FAMILY NAME: Belongs to the killer cell lectin-like superfamily.|
KLRF1 is a single-pass type-2 231 aa glycoprotein. It contains an 166 aa extracellular domain which contains a Ig-like C-type lectin domain with 6 invariant cys residues, a 23 aa transmembrane domain and a 42 aa cytoplasmic domain which contains 2 ITIM motifs.
MOLECULAR MASS: No information.
Alternative splicing yields 4 different isoforms.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH KLRF1: No information.|
|NK lectin-like receptors like KLRF1 may contain a ITIM motif. Upon MHC class I engagement and tyrosine phosphorylation of the ITIM, SHP1 is recruited to the ITIM and an inhibitory signal cascade which leads to the abrogation of NK cell activation. KLFR1 is involved in the natural killer-mediated cytolysis of PHA-induced lymphoblasts.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF KLFR1 IN INTACT ANIMAL: No information.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF KLFR1: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY KLFR1: No information.
Database accession numbers
Revised June 25, 2008