|CD236R||GYPD (Glycophorin D), [Gerbich blood group]|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
Type 3 glycoprotein
|30 / 30|
|CD236R is expressed on erythrocytes, erythroid cells, red cells and subsets of stem cells. Expression is in kidney, breast, thymus and adult liver at lower levels and with different glycosylation.|
|MOLECULAR FAMILY NAME: Belongs to the glycophorin family.|
CD236R is a single-pass type-3 128 aa glycoprotein. CD236R is a truncated form of CD236 arising from the use of an alternative translation initiation site at codon 30. The protein encoded by mRNA can not be expressed in the cell membrane because it lacks the
transmembrane and cytoplasmic domains. It lacks the first 21 N-terminal amimo acids, has fewer glycosylation sites and lacks the N-terminal oligosaccharide chain.
Alternative splicing yields 2 different isoforms. CD236R variant 1 includes all 4 exons and encodes the full length protein. Variant 2 is missing exon 2 and specifies the Yus phenotype.
POST-TRANSLATIONAL MODIFICATION: No information.
| LIGANDS AND MOLECULES ASSOCIATED WITH CD236R: No information.|
|CD236R is associated with the Gerbich blood group deficiency. It is a minor red-cell membrane component, representing about 4% of the membrane sialoglyoproteins in human erythrocyte membranes but shows little homology with the major red-cell membrane glycoproteins A and B. It plays an important role in regulating the mechanical stability of red cells and is a positive receptor for the merozoites of P. falciparum and are most likely located within the extracellular domain. It plays a role in the invasion and intraerythrocytic development of P. falciparum and determines the Gerbich blood group. The CD239R protein has very little homology with CD235A (GYPA) and CD235B (GYPB).|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD236R IN INTACT ANIMAL
Ahonen (ANA) is a rare blood group antigen found only on CD236R positive cells.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD236R: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD236R: No information.
Database accession numbers
Revised June 25, 2008