CD240CE RHCE(Rh blood group, CeEe antigens), Rh30CE
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Type 3 glycoprotein, 12 span
Erythrocyte
Red Cell
30 / 30

Expression
CD240CE is expressed on the surface of red blood cells and erythrocytes and is restricted to tissues or cell lines expressing erythroid progenitors at the CFU-E stage.

Structure
MOLECULAR FAMILY NAME: Belongs to the rhesus blood group family.

CD240CE is a multi-pass type-3, span 12, 417 aa glycoprotein.  It contains an extracellular domain,  12 transmembrane helical domains and 6 cysteine residues of which 3 are palmitoylated and a cytoplasmic domains which has a N- and C-termini located inside the cell.  
 
MOLECULAR MASS
Cell Type Unreduced Reduced
30-32 kDa

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 4 transcript variants encoding 4 different isoforms.

POST-TRANSLATIONAL MODIFICATION OF CD240CE

CD240CE is a non-glycosylated protein.



Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD240CE: No information.

Function
CD240CE belongs to the Rh blood group system.  CD240D is closely associated in the erythrocyte membrane with the Rh-associated glycoprotein CD241 (RhAG), CD242 (ICAM-4, LW), CD47 and CD235b (glycophorin B).  The core of the Rh complex is thought to consist of two Rh subunits and two CD241 subunits, to which CD47, CD235b and and CD242 associate noncovalently.  This system is one of the polymorphic in the blood group and is comprised of 45 antigens.  The Rh antigen may promote the export of ammonium.  The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic CD240CE protein on the surface of erythrocytes.   The function of this large complex is unclear but there is evidence to suggest CD240CE assists in maintaining the mechanical properties of the erythrocyte by association with ankyrin-R of the red cell skeleton.

The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO.  It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversion, and missense mutations.  The Rh blood group includes the CD240CE gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein.  The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of highly immunogenic RhD protein on the surface of erythrocytes.  CD240CE may be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD240CE IN INTACT ANIMAL: No information.


Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD240CE: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD240CE: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 6006P18577
Antibodies

Revised June 25, 2008


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