CD240DCE Rh30D/CE crossreactive mabs
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Type 3 glycoprotein, 12 span
Erythrocyte
Red Cell
30 / 30

Expression
CD240DCE is expressed on red blood cells and mature erythrocytes and erythroid progenitors.

Structure
MOLECULAR FAMILY NAME: Belongs to rhesus blood group family.

CD240DCE is a multi-pass type-3, span 12 417 aa glycoprotein.  It contains an extracellular domain, 12 transmembrane helical domains and cytoplasmic domain.  CD240DCE is the product of a hybrid gene RHD-CE-D that is created when a portion of the RHD gene ranging from one exon to several exons has been replaced by the equivalent region of RHCE.  This results in a hybrid protein that stably exists in the red cell membrane by lacks many D epitopes.

MOLECULAR MASS
Cell Type Unreduced Reduced
30-32 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

CD240DCE is non-glycosylated.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD240DCE: No information.

Function
CD240D belongs to the Rh blood group system.  CD240DCE is closely associated in the erythrocyte membrane with the Th-associated glycoprotein CD241 (RhAG), CD242 (ICAM-4, LW), CD47 and CD235b (glycophorin B).  The core of the Rh complex is thought to consist of two Rh subunits and two CD241 subunits, to which CD47, CD235b and and CD242 associate noncovalently.  This system is one of the polymorphic in the blood group and is comprised of 45 antigens.  The Rh antigen may promote the export of ammonium.  The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic CD240D protein on the surface of erythrocytes.   The function of this large complex is unclear but there is evidence to suggest CD240DCE assists in maintaining the mechanical properties of the erythrocyte by association with ankyrin-R of the red cell skeleton.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD240DCE IN INTACT ANIMAL: No information.


Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD240DCE: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD240DCE: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


Contact us: Webmaster |  509-335-9515 | Accessibility | Copyright | Policies
College of Veterinary Medicine Washington State University, Pullman, WA, 99164-7010 USA
Copyright 1995-2003 Washington State University