CD51/61 Vitronectin receptor
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Unknown
Platelet
Osteoclast
Endothelial Cell
Monocyte
Macrophage
Neutrophil
B Cell
Muscle Cell

Expression

CD61(aVb3) is expressed on endothelial cells platelets, certain cultured/activated monocytes, macrophages and neutrophils, some B cells and osteoclasts and on tissues including smooth muscle cells.



Structure
MOLECULAR FAMILY NAME:  See CD51

MOLECULAR MASS OF CD51/61:

POST-TRANSLATIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD51/61

Ligands for CD51/CD61 include RGD-containing proteins such as fibrinogen, fibronectin, von Willebrand factor (vWf), laminin, thrombospondin, bone sialoprotein (Bsp1) and the neural adhesion molecule L1, which is expressed on certain leukocytes.  CD51/CD61 also mediates cell-cell adhesion via an interaction with CD31.


Function
CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins, including matrix components.  It mediates leukocyte-endothelial cell adhesion via interaction with CD31. It has also been shown to initiate bone resorption by mediating the adhesion of osteoclasts to osteopontin, and it may play a role in angiogenesis. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD51/61 IN INTACT ANIMAL

Antagonists of CD51/CD61 have been shown to inhibit tumor growth by disrupting angiogenesis.


Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD51/61:No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD51/61: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies
23C6   View Reactivity

Revised June 25, 2008


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