|ICAM-5||ICAM-5(intracellular adhesion molecule), TLN, TLCN(telencephalin)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
Type 1 glycoprotein
|Neuron||125 / 135|
515 / 525
| ICAM-5 is expressed on neurons in the telencephalon of mammalian brain. No other expression has been observed. |
| MOLECULAR FAMILY NAME: intracellular adhesion molecule family -->immunoglobulin supergene family.|
ICAM-5 is a type 1 glycoprotein. It is a nueron-specific adhesion molecule in the telencephalon region of the brain that binds leukocytes. It is a member of the immunoglobulin superfamily of proteins and is closely related to other members of the ICAM-family. ICAM-5 is comprised of 9 Ig-like domains, 1 transmembrane region and 1 C-terminal cytoplasmic tail. The binding regions for leukocytes has been mapped. The binding region for leukocyte CD11a/CD18 integrin is in the 1st immunoglobulin domain and homophilic binding occurs via binding of the 1st domain to domains 4-5.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
ICAM-5 is N-glycosylated but probably not O-glycosylated. No details are known about its carbohydrate chains. HNK-1 carbohydrate antigen is present in ICAM-5. The possible phosphorylation of ICAM-5 has not been studied. ICAM-5 is also found in soluble form in the cerebrospinal fluid, evidently due to proteolytic cleavage.
| LIGANDS AND MOLECULES ASSOCIATED WITH ICAM-5|
| ICAM-5 is a ligand that binds to the leukocyte integrin CD11a/CD18 LFA-1 but it also shows homophilic binding and therefore it may be important in neuron-neuron binding. ICAM-5 is a stimulatory molecule for dendritic outgrowth. During development in the rat it shows a monomer/high molecular weight switch, which co-relates with the time of dendrite formation.|
ICAM-5 is not known to have any enzymatic function. The main activity of ICAM-5 is in cellular adhesion.
DISEASE RELEVANCE AND FUNCTION OF ICAM-5 IN INTACT ANIMAL
Little is known about the in vivo function of ICAM-5. ICAM-5 may be important for the interaction of microglia cells with neurons and also for neuron-neuron interaction. Furthermore ICAM-5 may be important for dendritic formation during development and is involved in long term potentiation of synaptic transmission in hippocampus. A soluble form of ICAM-5 is found in the cerebrospinal fluid, in plasma and the levels increase during inflammation and other conditions in the brain.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF ICAM-5: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY ICAM-5: No information.
Database accession numbers
Revised June 25, 2008