CD158z KIR3DL3 (killer cell immunoglobulin-like receptor, 3 domains, long cytoplasmic tail, 3)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
NK Cell
T Cell

Expression
CD158z is expressed on subsets of NK cells, on subsets of cytotoxic cells and some T cells.  Expression on individual NK cells is complex and several members of the KIR family.  The repertoire of KIR molecules varies among NK cells and is not determined solely by the HLA hapotypes.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene superfamily.

CD158z is a single-pass type-1 410 aa glycoprotein.  It contains a N-terminal signal sequence, an extracellular domain which contains 3 Ig-like C2-type domains (D0, D1 and D2), a transmembrane domain lacking a positively charged residue and a 84-95 aa long cytoplasmic domain containing 2 ITIM motifs. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD158z

HLA-class 1 allotypes are the ligands for CD158 molecules.

Function
CD158z is involved in the suppression of NK cell mediated cytotoxicity and may prevent cell lysis.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD158z IN INTACT ANIMAL: No information.


Comments

Killer cell immunoglobulin (Ig)-like receptors (KIR), also called killer cell inhibitory receptors, are glycoproteins expressed in natural killer (NK) cells and some T cells.  The KIR family is estimated to include about 11 genes.  Some members of the KIR family bind to certian HLA class allotypes.  Ligation of such KIR by HLA class I molecules on target cells results in inhibition of the NK or T cell cytotoxic activity.  The KIR family is subdivided into 2 subfamilies based on structure, 2 Ig domains (KIR2D) and 3 Ig domains (KIR3D), with further subdivision into forms with short and long intracytoplasmic tails. The 1st and 2nd Ig domains in KIR2D are closely related in aa sequence to the 2nd and 3rd Ig domains in KIR3D. These 2 related Ig domains are called D1 and D2, respectively.  D0 is the 1st Ig domain in KIR3D.  Kir members vary in the length of the cytoplasmic tails.  Most of the long cytoplasmic tails, KIR2DL and KIR3DL, deliver an inhibitory signal and carry 2 immunoreceptor tyrosine-based inhibition motifs (ITIM) which recruit and activate protein tyrosine phosphates, SHP-1 and or SHP-2.  The short cytoplasmic tails are truncated before the 1st ITIM and are connected to a transmembrane region which includes a lysine residue and can activate NK or T cell responses.  The short tail associates with a disulfide dimer of 14 kDa. phosphoproteins called DAP12 which is also known as killer activating protein (KARAP).

MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD158z: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD158z: No information.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrez115653Q8N743
Antibodies

Revised June 25, 2008


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