CD85b ILT8 (immunoglobulin-like transcripts-8), LILRA6 (leukocyte immunoglobulin-like receptor, subfamily A with TM domain, member 6)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
NK Cell
T Cell
Monocyte
Macrophage
Dendritic Cell
B Lymphocyte

Expression
CD85b is expressed on NK and T cell subsets, monocytes, macrophages, dendritic cells and B lymphocytes.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.

CD85b is a single-pass type-1 glycoprotein.  It contains an extracellular domain, a transmembrane domain and a short cytoplasmic tail which lacks ITIMs.  The ILT/LIR family is a member of the Ig gene superfamily.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.



Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD85b: No information.

Function
CD85b is involved in the activation of NK-mediated cytotoxicity and binds the FcRγ chain.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD85b IN INTACT ANIMAL: No information.


Comments
Previously, the ILT family was clustered together as CD85.  Recently subclassifications have been given to individual members listed as CD85a - CD85m.  Ig-like transcripts (ITLs) and leukocyte Ig-like transcripts (LIRs) are structurally and functionally related transmembrane glycoproteins.  The receptors are divided into 2 groups of inhibitory and activating receptors according to the nature of their transmembrane and cytoplasmic regions.  Receptors with a long cytoplasmic tail, CD85a (ILT5/LIR3), CD85c (LIR8), CD85d (ILT4/LIR2), CD85j (ILT2/LIR1) and CD85k (ILT3/LIR5), contain one or more intracytoplasmic ITIMs which recruit and activate protein tyrosine phosphates SHP-1 and/or SHP-2.  Receptors with a short tail, CD85b (ILT8), CD85f (ILT11), CD85g (ILT7), CD85h (ILT1/LIR7) and CD85i (LIR6a) lack ITIMs and contain a positively charged aa residue, arginine or lysine, in their transmembrane domain which is necessary for association with ITIM-containing polypeptides like FcRg chain.  CD85l (ILT9) and CD85m (ILT10) bind the FcRg chain.  Phosphorylated ITAMs recruit the protein tyrosine kinases Syk and ZAP70.  One exception to these transmembrane receptors is CD85e (ILT6/LIR4) which has no transmembrane or cytoplasmic domains and is probably soluble.                     

MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD85b: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD85b: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntregene79168Q6P173
Antibodies

Revised June 25, 2008


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