CD85c LIR8 (leukocyte immunogobulin-like receptor-8), LILRB5 (leukocyte immunoglobulin-like receptor, subfamily B with TM and ITIM domains, member 5)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
NK Cell
T Cell
Monocyte
Macrophage
Dendritic Cell
B Lymphocyte

Expression
CD85c is expressed on T cell subsets, monocytes, macrophages, dendritic cells and B lymphocytes.  Expression is predominantly in NK cells.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.

CD85c is a single-pass type 1 glycoprotein.  It contains an extracellular domain which contains 4 Ig-like C2-type domains, a 590 aa transmembrane and a long cytoplasmic domain containing 2 ITIM motifs.  The motifs are involved in moduation of cellular responses.  The ILT/LIR family is a member of the Ig gene superfamily.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION

The phosphorylation ITIM motif can bind the Sh2 domain of several SH2-containing phosphatases.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD85c: No information

Function
CD85c is involved in the activation of NK-mediated cytotoxicity and binds the FcRγ chain.  CD85c may act as a receptor for MHC class I antigens.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD85c IN INTACT ANIMAL: No information.


Comments
Previously, the ILT family was clustered together as CD85.  Recently subclassifications have been given to individual members listed as CD85a - CD85m.  Ig-like transcripts (ITLs) and leukocyte Ig-like transcripts (LIRs) are structurally and functionally related transmembrane glycoproteins.  The receptors are divided into 2 groups of inhibitory and activating receptors according to the nature of their transmembrane and cytoplasmic regions.  Receptors with a long cytoplasmic tail, CD85a (ILT5/LIR3), CD85c (LIR8), CD85d (ILT4/LIR2), CD85j (ILT2/LIR1) and CD85k (ILT3/LIR5), contain one or more intracytoplasmic ITIMs which recruit and activate protein tyrosine phosphates SHP-1 and/or SHP-2.  Receptors with a short tail, CD85b (ILT8), CD85f (ILT11), CD85g (ILT7), CD85h (ILT1/LIR7) and CD85i (LIR6a) lack ITIMs and contain a positively charged aa residue, arginine or lysine, in their transmembrane domain which is necessary for association with ITIM-containing polypeptides like FcRg chain.  CD85l (ILT9) and CD85m (ILT10) bind the FcRg chain.  Phosphorylated ITAMs recruit the protein tyrosine kinases Syk and ZAP70.  One exception to these transmembrane receptors is CD85e (ILT6/LIR4) which has no transmembrane or cytoplasmic domains and is probably soluble.                     

MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD85c: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD85c: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene10990O75023
Antibodies

Revised June 25, 2008


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