CD85e ILT6 (immunoglobulin-like transcript-6), LIR4 (leukocyte immunoglobulin-like receptor-4), LILRA3 (leukocyte immunoglobulin-like receptor subfamily A, without TM domain, member 3)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Monocyte
Peripheral blood
Lung
NK Cell
B Cell

Expression
CD85e is expressed on B cells and at lower levels in NK cells and not in T cell subsets, monocytes, macrophages, dendritic cells and B lymphocytes.  Expression is detected in peripheral blood monocytes and lung.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.

CD85e is a single-pass type-2 439 aa glycoprotein.  It contains an extracellular domain which contains 4 Ig-like C2-type domains but there is no transmembrane or cytoplasmic domains.  The ILT/LIR family is a member of the Ig gene superfamily.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD85e: No information.

Function
CD85e is involved in the activation of NK-mediated cytotoxicity and binds the FcRγ chain.  CD85e may act as a soluble receptor for MHC class I antigens.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD85e IN INTACT ANIMAL: No information.


Comments
Previously, the ILT family was clustered together as CD85.  Recently subclassifications have been given to individual members listed as CD85a - CD85m.  Ig-like transcripts (ITLs) and leukocyte Ig-like transcripts (LIRs) are structurally and functionally related transmembrane glycoproteins.  The receptors are divided into 2 groups of inhibitory and activating receptors according to the nature of their transmembrane and cytoplasmic regions.  Receptors with a long cytoplasmic tail, CD85a (ILT5/LIR3), CD85c (LIR8), CD85d (ILT4/LIR2), CD85j (ILT2/LIR1) and CD85k (ILT3/LIR5), contain one or more intracytoplasmic ITIMs which recruit and activate protein tyrosine phosphates SHP-1 and/or SHP-2.  Receptors with a short tail, CD85b (ILT8), CD85f (ILT11), CD85g (ILT7), CD85h (ILT1/LIR7) and CD85i (LIR6a) lack ITIMs and contain a positively charged aa residue, arginine or lysine, in their transmembrane domain which is necessary for association with ITIM-containing polypeptides like FcRg chain.  CD85l (ILT9) and CD85m (ILT10) bind the FcRg chain.  Phosphorylated ITAMs recruit the protein tyrosine kinases Syk and ZAP70.  One exception to these transmembrane receptors is CD85e (ILT6/LIR4) which has no transmembrane or cytoplasmic domains and is probably soluble.                     

MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD85e: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD85e: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene11026Q8N6C8
Antibodies

Revised June 25, 2008


Contact us: Webmaster |  509-335-9515 | Accessibility | Copyright | Policies
College of Veterinary Medicine Washington State University, Pullman, WA, 99164-7010 USA
Copyright 1995-2003 Washington State University