CD85f ILT11(immunoglobulin-like transcript-11), LIR9 (leukocoyte immunoglobulin-like receptor-9) LILRA5 (leukocyte immunoglobulin-like receptor subfamily A with TM domain, member 5)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Monocyte
Macrophage
Dendritic Cell
B Lymphocyte
Hematopoietic Cell
Peripheral blood
Neutrophil
Leukocyte
Bone Marrow
Spleen
Lymph Node
35 / 35

Expression
CD85f is expressed mainly on PBL.  CD85f is not expressed on NK cell, B cells and T cell subsets, but is expressed on monocytes, leukocytes, neutrophils, macrophages, dendritic cells and B lymphocytes.  Expression was seen in tissues of hematopoietic system, bone marrow, spleen, lymph node and peripheral leukocytes.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.

CD85f is a single-pass type-1 glycoprotein.  It contains a N-terminal signal peptide, an extracellular domain with 2 Ig-like C2-type domains, a transmembrane domain and a short cytoplasmic tail lacking ITIMs.  The ILT/LIR family is a member of the Ig gene superfamily.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD85f: No information.

Function
CD85f is involved in the activation of NK-mediated cytotoxicity and binds the FcRγ chain.  Crosslinking of CD85f on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the role in triggering innate immune responses.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD85f IN INTACT ANIMAL: No information.


Comments
Previously, the ILT family was clustered together as CD85.  Recently subclassifications have been given to individual members listed as CD85a - CD85m.  Ig-like transcripts (ITLs) and leukocyte Ig-like transcripts (LIRs) are structurally and functionally related transmembrane glycoproteins.  The receptors are divided into 2 groups of inhibitory and activating receptors according to the nature of their transmembrane and cytoplasmic regions.  Receptors with a long cytoplasmic tail, CD85a (ILT5/LIR3), CD85c (LIR8), CD85d (ILT4/LIR2), CD85j (ILT2/LIR1) and CD85k (ILT3/LIR5), contain one or more intracytoplasmic ITIMs which recruit and activate protein tyrosine phosphates SHP-1 and/or SHP-2.  Receptors with a short tail, CD85b (ILT8), CD85f (ILT11), CD85g (ILT7), CD85h (ILT1/LIR7) and CD85i (LIR6a) lack ITIMs and contain a positively charged aa residue, arginine or lysine, in their transmembrane domain which is necessary for association with ITIM-containing polypeptides like FcRg chain.  CD85l (ILT9) and CD85m (ILT10) bind the FcRg chain.  Phosphorylated ITAMs recruit the protein tyrosine kinases Syk and ZAP70.  One exception to these transmembrane receptors is CD85e (ILT6/LIR4) which has no transmembrane or cytoplasmic domains and is probably soluble.                     

MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD85f: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD85f: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


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