|CD85g||ILT7 (immunoglobulin-like transcript-7), LILRA4 (immunoglobulin-like receptor subfamily A with TM domain, member 4)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
| CD85g is expressed on NK and T cell subsets, monocytes, macrophages, plasmacytoid dendritic cells and B lymphocytes. Expression on plasmacytoid dendritic cells is found to be rapidly down related by IL-3. Expression is detected on eosinophils and neutrophils. |
|MOLECULAR FAMILY NAME: Belongs to the immunolgobulin supergene family.|
CD85g is a single-pass type-1 glycoprotein. It contains an extracellular domain which contains 4 Ig-like C2-type domains, a transmembrane domain and a short cytoplasmic tail lacking ITIMs. The ILT/LIR family is a member within the Ig gene superfamily.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD85g: |
Ligand binding leads to activation of eosinophils and to the release of RNASE2, IL-4 and leukotriene.
|CD85g is involved in the activation of NK-mediated cytotoxicity and binds the FcRγ chain. CD85g may act as a receptor for MHC class I antigens. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD85g IN INTACT ANIMAL: No information.
|Previously, the ILT family was clustered together as CD85. Recently subclassifications have been given to individual members listed as CD85a - CD85m. Ig-like transcripts (ITLs) and leukocyte Ig-like transcripts (LIRs) are structurally and functionally related transmembrane glycoproteins. The receptors are divided into 2 groups of inhibitory and activating receptors according to the nature of their transmembrane and cytoplasmic regions. Receptors with a long cytoplasmic tail, CD85a (ILT5/LIR3), CD85c (LIR8), CD85d (ILT4/LIR2), CD85j (ILT2/LIR1) and CD85k (ILT3/LIR5), contain one or more intracytoplasmic ITIMs which recruit and activate protein tyrosine phosphates SHP-1 and/or SHP-2. Receptors with a short tail, CD85b (ILT8), CD85f (ILT11), CD85g (ILT7), CD85h (ILT1/LIR7) and CD85i (LIR6a) lack ITIMs and contain a positively charged aa residue, arginine or lysine, in their transmembrane domain which is necessary for association with ITIM-containing polypeptides like FcRg chain. CD85l (ILT9) and CD85m (ILT10) bind the FcRg chain. Phosphorylated ITAMs recruit the protein tyrosine kinases Syk and ZAP70. One exception to these transmembrane receptors is CD85e (ILT6/LIR4) which has no transmembrane or cytoplasmic domains and is probably soluble. |
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD85g: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD85g: No information.
Database accession numbers
Revised June 25, 2008