CD85h ILT1 (immunoglobulin-like transcript-1), LIR7 (leukocyte immunoglobulin-like receptor-7), LILRA2 (leukocyte immunoglobulin-like receptor subfamily A with TM domain, member 2)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Monocyte
Myeloid Cell
B Cell

Expression
CD85h is expressed at levels that are very low or not dectable on T cell subsets,  macrophages, dendritic cells and some NK cells.  CD85h is expressed on monocytes, myeloid cells and in some B-cell lines. 

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.

CD85h is a single-pass type-1 466 aa transmembrane glycoprotein.  It contains a 23 aa signal peptide, an extracellular domain which contains 4 Ig-like C2-type domains, a 19 aa transmembrane domain containing a charge arginine at position 3 which may initiate stimulatory cascades and a 15 aa short cytoplasmic tail lacking ITIMs.  The ILT/LIR family is a member within the Ig gene superfamily.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD85h: No information.

Function
CD85h is involved in the activation of NK-mediated cytotoxicity and binds the FcRγ chain.  CD85h may act as a receptor for MHC class I antigens.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD85h IN INTACT ANIMAL: No information.


Comments
Previously, the ILT family was clustered together as CD85.  Recently subclassifications have been given to individual members listed as CD85a - CD85m.  Ig-like transcripts (ITLs) and leukocyte Ig-like transcripts (LIRs) are structurally and functionally related transmembrane glycoproteins.  The receptors are divided into 2 groups of inhibitory and activating receptors according to the nature of their transmembrane and cytoplasmic regions.  Receptors with a long cytoplasmic tail, CD85a (ILT5/LIR3), CD85c (LIR8), CD85d (ILT4/LIR2), CD85j (ILT2/LIR1) and CD85k (ILT3/LIR5), contain one or more intracytoplasmic ITIMs which recruit and activate protein tyrosine phosphates SHP-1 and/or SHP-2.  Receptors with a short tail, CD85b (ILT8), CD85f (ILT11), CD85g (ILT7), CD85h (ILT1/LIR7) and CD85i (LIR6a) lack ITIMs and contain a positively charged aa residue, arginine or lysine, in their transmembrane domain which is necessary for association with ITIM-containing polypeptides like FcRg chain.  CD85l (ILT9) and CD85m (ILT10) bind the FcRg chain.  Phosphorylated ITAMs recruit the protein tyrosine kinases Syk and ZAP70.  One exception to these transmembrane receptors is CD85e (ILT6/LIR4) which has no transmembrane or cytoplasmic domains and is probably soluble.                     

MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD85h: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD85h: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene11027Q8H149
Antibodies

Revised June 25, 2008


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