|CD85i||ILR6 (immunoglobulin-like receptor-6), LILRA1 (leukocyte immunoglobulin-like receptor, subfamily A with TM domain, member 1)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
| CD85i is expressed on T cell subsets, monocytes, macrophages, dendritic cells and B lymphocytes. |
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.|
CD85i is a single-pass type-1 489 aa transmembrane glycoprotein. It contains a 289 aa extracellular domain which contains 4 Ig-like C2-type domains with a truncated variant of 289 aa with only the first 2 Ig domains, a transmembrane with a charged arginine residue at position 3 which may initiate stimulatory cascades and a short cytoplasmic tail which lacks ITIMs. The ILT/LIR family is a member within the Ig gene superfamily.
Alternative splicinh yields 2 different isoforms.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD85i: No information.|
|CD85i is involved in the activation of NK-mediated cytotoxicity and binds the FcRγ chain. CD85i may act as a receptor for MHC class I antigens.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD85i IN INTACT ANIMAL: No information.
|Previously, the ILT family was clustered together as CD85. Recently subclassifications have been given to individual members listed as CD85a - CD85m. Ig-like transcripts (ITLs) and leukocyte Ig-like transcripts (LIRs) are structurally and functionally related transmembrane glycoproteins. The receptors are divided into 2 groups of inhibitory and activating receptors according to the nature of their transmembrane and cytoplasmic regions. Receptors with a long cytoplasmic tail, CD85a (ILT5/LIR3), CD85c (LIR8), CD85d (ILT4/LIR2), CD85j (ILT2/LIR1) and CD85k (ILT3/LIR5), contain one or more intracytoplasmic ITIMs which recruit and activate protein tyrosine phosphates SHP-1 and/or SHP-2. Receptors with a short tail, CD85b (ILT8), CD85f (ILT11), CD85g (ILT7), CD85h (ILT1/LIR7) and CD85i (LIR6a) lack ITIMs and contain a positively charged aa residue, arginine or lysine, in their transmembrane domain which is necessary for association with ITIM-containing polypeptides like FcRg chain. CD85l (ILT9) and CD85m (ILT10) bind the FcRg chain. Phosphorylated ITAMs recruit the protein tyrosine kinases Syk and ZAP70. One exception to these transmembrane receptors is CD85e (ILT6/LIR4) which has no transmembrane or cytoplasmic domains and is probably soluble. |
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD85i: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD85i: No information.
Database accession numbers
Revised June 25, 2008