CD85m ILT10, LILRP1 (leukocyte immunoglobulin-like receptor pseudogene 1)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
T Cell
Monocyte
Macrophage
Dendritic Cell
B Lymphocyte

Expression
CD85m is expressed on T cell subsets, monocytes, macrophages, dendritic cells and B lymphocytes.

Structure
MOLECULAR FAMILY NAME: Belongs to the  immunoglobulisupergene family.

CD85m is a single-pass type-1 transmembrane glycoprotein.  It belongs to the ILT/LIR family within the Ig gene superfamily.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD85m:

CD85m binds FcRg.


Function
CD85m binds the FcRγ chain.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD85m IN INTACT ANIMAL: No information.


Comments
Previously, the ILT family was clustered together as CD85.  Recently subclassifications have been given to individual members listed as CD85a - CD85m.  Ig-like transcripts (ITLs) and leukocyte Ig-like transcripts (LIRs) are structurally and functionally related transmembrane glycoproteins.  The receptors are divided into 2 groups of inhibitory and activating receptors according to the nature of their transmembrane and cytoplasmic regions.  Receptors with a long cytoplasmic tail, CD85a (ILT5/LIR3), CD85c (LIR8), CD85d (ILT4/LIR2), CD85j (ILT2/LIR1) and CD85k (ILT3/LIR5), contain one or more intracytoplasmic ITIMs which recruit and activate protein tyrosine phosphates SHP-1 and/or SHP-2.  Receptors with a short tail, CD85b (ILT8), CD85f (ILT11), CD85g (ILT7), CD85h (ILT1/LIR7) and CD85i (LIR6a) lack ITIMs and contain a positively charged aa residue, arginine or lysine, in their transmembrane domain which is necessary for association with ITIM-containing polypeptides like FcRg chain.  CD85l (ILT9) and CD85m (ILT10) bind the FcRg chain.  Phosphorylated ITAMs recruit the protein tyrosine kinases Syk and ZAP70.  One exception to these transmembrane receptors is CD85e (ILT6/LIR4) which has no transmembrane or cytoplasmic domains and is probably soluble.                     

MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD85m: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD85m: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


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