CD37 gp52-40, Tspan-26
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Type 3 glycoprotein, 4 span
Myelomonocytic cell
T Cell
Neutrophil
Monocyte
Leukemia cell
Granulocyte
B Cell
40 / 40
64 / 64

Expression
CD37 is highly expressed on normal and neoplastic mature sIg positive B cells, but not on pre-B cells or plasma cells.  There is low expression on resting and activated T cells, neutrophils, monocytes, granulocytes and some myelomonocytic leukemia cells.  CD37 is not expressed on NK cells, platelets or erythrocytes.  Immunoelectron microscopy has shown that a large proportion of CD37 protein is present in intracellular vesicles.


Structure
MOLECULAR FAMILY NAME:  Belongs to the tetraspan family.

CD37 is a multi-pass type-3, 4 span 281 aa glycoprotein.  It contains 2 extracellular domains which contains 3 heavily N-glycosylation sites with generally only 2 sites are occupied but no O-carbohydrate, 4 hydrophobic transmembrane domains and a short cytoplasmic N- and C-termini.  Gene mapping data suggest that CD37 and CD53 have evolved by gene duplication and divergence from a common ancestral gene.

MOLECULAR MASS
Cell Type Unreduced Reduced Comment
Lymphoblastoid B cell line 40-64 kDa 40-64 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

CD37 is heavily N-glycosylated, has a protein core of 26 kDa and generally 2 N-glycosylation sites are used, but sometimes a 3rd site is occupied.

Ligands
CD37 on B cells associates non-covalently with MHC Class II, CD19, CD21 and the TM4SF molecules CD53, CD81 and CD82. No extracellular ligand has been identified for CD37.

LIGANDS AND MOLECULES ASSOCIATED WITH CD37
Molecule Comment
CD53
Large complexes at the surface of B are composed of CD37, CD53, CD81 and CD82 together with MHC class II molecules

CD81
Large complexes at the surface of B are composed of CD37, CD53, CD81 and CD82 together with MHC class II molecules

CD82
Large complexes at the surface of B are composed of CD37, CD53, CD81 and CD82 together with MHC class II molecules

MHC class II

Large complexes at the surface of B are composed of CD37, CD53, CD81 and CD82 together with MHC class II molecules




Function
CD37 forms complexes in the B cell membrane with CD53, CD81, CD82 and MHC class II which may be involved in antigen transport and processing.  CD37 function is involved in signal transduction that plays a role in the regulation of cell development, activation, growth and motility.  Knockout mice show normal hematopoietic cell development but have impaired T-cell-dependent B-cell responses.  These mice have altered TCR signaling, increased T-cell proliferation, increased IL-2 production, as well as increased kinase activity of Lck, which suggests a regulatory role for CD37 in T cell proliferation.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD37 IN INTACT ANIMAL

CD37 is a stable marker for malignancies derived from mature B cells, like B-CLL, HCL, and all types of B-NHL and B cell malignancies.

Comments
MOLECULAR INTERACTION -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD37: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD37: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 951P11049
MouseU18367-U18372
RatB47629P31053X53517
Antibodies
M-B371   View Reactivity
WR17   View Reactivity

Revised June 25, 2008


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