|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
Type 3 glycoprotein, 4 span
|40 / 40|
64 / 64
| CD37 is highly expressed on normal and neoplastic mature sIg positive B cells, but not on pre-B cells or plasma cells. There is low expression on resting and activated T cells, neutrophils, monocytes, granulocytes and some myelomonocytic leukemia cells. CD37 is not expressed on NK cells, platelets or erythrocytes. Immunoelectron microscopy has shown that a large proportion of CD37 protein is present in intracellular vesicles.|
|MOLECULAR FAMILY NAME: Belongs to the tetraspan family.|
CD37 is a multi-pass type-3, 4 span 281 aa glycoprotein. It contains 2 extracellular domains which contains 3 heavily N-glycosylation sites with generally only 2 sites are occupied but no O-carbohydrate, 4 hydrophobic transmembrane domains and a short cytoplasmic N- and C-termini. Gene mapping data suggest that CD37 and CD53 have evolved by gene duplication and divergence from a common ancestral gene.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
CD37 is heavily N-glycosylated, has a protein core of 26 kDa and generally 2 N-glycosylation sites are used, but sometimes a 3rd site is occupied.
|CD37 on B cells associates non-covalently with MHC Class II, CD19, CD21 and the TM4SF molecules CD53, CD81 and CD82. No extracellular ligand has been identified for CD37.|
LIGANDS AND MOLECULES ASSOCIATED WITH CD37
|CD37 forms complexes in the B cell membrane with CD53, CD81, CD82 and MHC class II which may be involved in antigen transport and processing. CD37 function is involved in signal transduction that plays a role in the regulation of cell development, activation, growth and motility. Knockout mice show normal hematopoietic cell development but have impaired T-cell-dependent B-cell responses. These mice have altered TCR signaling, increased T-cell proliferation, increased IL-2 production, as well as increased kinase activity of Lck, which suggests a regulatory role for CD37 in T cell proliferation.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD37 IN INTACT ANIMAL
CD37 is a stable marker for malignancies derived from mature B cells, like B-CLL, HCL, and all types of B-NHL and B cell malignancies.
|MOLECULAR INTERACTION -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD37: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD37: No information.
Database accession numbers
Revised June 25, 2008