CD156c ADAM-10 (a disintegrin and metalloproteinase-10)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Broad
Leukocyte
Tumor Cell
Chondrocyte
Brain
Liver
Spleen
Thymus
Bone Marrow
Lymph Node
Nervous system
Peripheral blood
70 / 70
97 / 97

Expression
CD156c expression is broad.  It is expressed on leukocytes, tumor cells, brain cells, articular chondrocytes, non-lymphoid and lymphoid tissues, peripheral blood, cartilage and fetal liver.  Expression is in the spleen, lymph node, thymus, peripheral blood leukocyte and bone marrow. Expression is induced in arthritic tissues and in the inflamed central nervous system.

Structure
MOLECULAR FAMILY NAME: Belongs to the disintregrin and metalloprotease family.

CD156c is a single-pass type-1 748 aa glycoprotein.  It contains a N-terminal signal sequence, an extracellular domain which contains a pro-domain that is cleaved before the molecule becomes catalytically active, a catalytic (zinc-dependent metalloprotease) domain followed by a cysteine-rich region chacteristic of disintegrins,an EGF-like domain and 4 potential N-linked glycosylation sites, a 23 aa transmembrane domain and a 129 aa C-terminal cytoplasmic domain. 

MOLECULAR MASS
Cell Type Unreduced Reduced
97 kDa 70 kDa




POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION:

CD156c has 4 potential N-glycosylation sites.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD156c

CD156c binds TNF-α, APP and Notch.  TNFα and Ephrin A2 are substrates.

Function
CD156c is an endopeptidase of broad specificity and is responsible for the proteolytic release of several other cell-surface proteins, including TNFα, heparin binding epidermal growth-like factor, ephrin-A2 and CD171.  Although expressed on the cell surface, it is mostly localized in the Golgi.  CD156c is also involved in the constitutive and regulated α-secretase cleavage of amyloid precursor protein (APP) and contributes to the normal cleavage of the cellular prion protein.  CD156c is involved in metalloprotease activity and cell-cell and cell-matrix interaction. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE REVELANCE AND FUNCTION OF CD156c IN INTACT ANIMAL

CD156c is thought to be involved in myelin degration in multiple sclerosis and its upregulation in inflamed CNS and joint tissue makes it a potential therapeutic target.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD156c: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD156c: No information.

ADDITIONAL INSIGHTS

For further information see Wolfsberg, T.G. et al (1995) J. Cell Biol. 131: 275-278).


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 102O14672
Antibodies

Revised June 25, 2008


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