CD159c KLRC2 (killer cell lectin-like receptor subfamily C, member 2), NKG2C
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
NK Cell
T Cell
26 / 26
36 / 36

Expression
CD159c is expressed on NK cells and CD8+ T cell subsets.

Structure
MOLECULAR FAMILY NAME:  Belongs to the killer cell lectin family.

CD159c is a single-pass type-2 231 aa glycoprotein.  It contains an extracellular domain which contains a C-type lectin domain , a transmembrane domain and a cytoplasmic domain with no ITIM motifs. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD159c

CD159c associates with CD94, MHC class I and binds HLA-E as a ligand for NKG2C.

Function
NK cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation.  They can regulate specific humoral and cell-mediated immunity.  NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK function.  The KLRC (NKG2) gene family is located within the NK complex.  CD159c is a receptor which exists as a heterodimer together with CD94.  CD159c plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T cells.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD159c IN INTACT ANIMAL

CD159c is absent from over 40% of healthy individuals of a homozygous deletion mutant.  While there are no strong associations, CD159c has been investigated for association with arthritis because the gene is in the region associated with rheumatoid disease.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD159c: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD159c: No information.

ADDITIONAL INSIGHTS

For further information see Braud, V. M. et al (1998) Nature 391: 795-799.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3822P26717
Antibodies

Revised June 25, 2008


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