|CD159c||KLRC2 (killer cell lectin-like receptor subfamily C, member 2), NKG2C|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 2 glycoprotein
|26 / 26|
36 / 36
|CD159c is expressed on NK cells and CD8+ T cell subsets.|
|MOLECULAR FAMILY NAME: Belongs to the killer cell lectin family.|
CD159c is a single-pass type-2 231 aa glycoprotein. It contains an extracellular domain which contains a C-type lectin domain , a transmembrane domain and a cytoplasmic domain with no ITIM motifs.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD159c|
CD159c associates with CD94, MHC class I and binds HLA-E as a ligand for NKG2C.
|NK cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK function. The KLRC (NKG2) gene family is located within the NK complex. CD159c is a receptor which exists as a heterodimer together with CD94. CD159c plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T cells.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD159c IN INTACT ANIMAL
CD159c is absent from over 40% of healthy individuals of a homozygous deletion mutant. While there are no strong associations, CD159c has been investigated for association with arthritis because the gene is in the region associated with rheumatoid disease.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD159c: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD159c: No information.
For further information see Braud, V. M. et al (1998) Nature 391: 795-799.
Database accession numbers
Revised June 25, 2008