|CD172g|| SIRPγ (signal regulatory protein γ), SIRPβ2|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|55 / 55|
|CD172γ is expressed on a proportion of B cell, a majority of activated T cells and NK cells. Expression is on the liver and at lower levels in many tissues, brain, heart, lung, pancreas, kidney, placenta and skeletal muscle.|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene superfamily. |
CD172γ is a single-pass type-1 354 aa transmembrane glycoprotein. It contains a putative signal sequence, a long extracellular domain which contains a N-terminal 2 Ig-like C1-type domains and 1 Ig-like V-type domain, a transmembrane region and a short intracellular domain and no catalytic domain. The structure is similar to that of CD172β in that it has a truncated cytoplasmic tail with no known motifs but it lacks the charged lysine residue required for interaction with DAP-12. CD172γ is highly homologous to signal-regulatory protein, CD172β (SIRPβ), suggesting that it seems to be a new member of the SIRP family. The protein encoded by CD172γ is a member of the signal-regulatory protein (SIRP) family and also belongs to the Ig superfamily.
Alternative splicing yields 2 different isoforms. Isoform 1 has 3 C Ig-like C-type domains and isoform 2 lacks the 2 Ig-like C-typ2 domains and does not appear to be expressed on the cell surface.
POST-TRANSLATIONAL MODIFICATION: No information.
LIGANDS AND MOLECULE ASSOCIATED WITH CD172γ
|CD172 (SIRP) family members are known to be involved in the negative regulation of receptor tyrosine-kinase coupled signaling processes and is involved in cell adhesion and costimulation. CD172γ may play a role in T-cell-T-cell signaling via CD47 and thus influence T-cell behavior. Ligation of CD47 by CD172γ was shown to induce apoptosis of T-cell lines, although not as efficiently as CD172α. The binding of CD172γ was found to be dependent on the level of CD47 expression on target cells.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD172γ IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD172γ: No information.
SUSBTRATES: No information.
ENZYMES WHICH MODIFY CD172γ: No information
For further information see Ichigotani, Y. et al (2000) J. Hum. Genet. 45: 378-382.
Database accession numbers
Revised June 25, 2008