CD185 BLR1 (Burkitt lymphoma receptor 1, GTP binding protein (chemokine [C-X-C motif] receptor 5) (* See 
available information under CD CKR), CXCR5
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 3 glycoprotein, 7 span
B Cell
T Cell
Neuron
Burkitt lymphoma cell
Monocyte
42 / 42

Expression

CD185 is expressed by T cell subsets, monocytes and mature B cells.  Expression is also on cerebellar neurons and Burkett lymphoma cells.



Structure
MOLECULAR FAMILY NAME: Belongs to the chemokine receptor family.

CD185 is a multi-pass type-3, 7 span glycoprotein.  It contains an extracelluler domain which contains 2 potential N-glycosylation sites, 7 transmembrane-spanning domains and a cytoplasmic carboxyl terminal domain.  CD185 is a chemokine receptor which are G-protein coupled receptors which form a division of the leukocyte chemoattractant subfamily which is part of the rhodopsin family of GPCRs.
 
MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.  One isoform lacks the first 45 aa of the 55 aa first N-terminal extracellular region.

POST-TRANSLATIONAL MODIFICATION

CD185 has two potential glycosylatuion sites.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD185: No information.

Function
CD185 acts as the receptor for the CXCL13 chemokine and the binding induces a chemotactic response.  CD185 associates with chemokine BLC (a B lymphocyte chemoattractant) and is identified to be a specific ligand for this receptor.  The localization of B cell migration and localization appears to depend on a balance between response by CD185 to BCL and CCR7 which is the receptor for two chemokines that attract B cell to the T-cell zones.    Studies of CD185 and its mouse counterpart strongly suggest the essential function of CD185 in B cell migration and localization within specific anatomic compartments, such as primary or secondary follicles in secondary lymphoid tissues, in lymph nodes as well as in spleen.  CD185 knockout mice show abnormal B-cell migration and disrupted B cell primary follicule formation.  Secondary follicules with germinal centers do form but in abnormal sites.  There is a possible regulatory function in Burkitt lymphomagenesis and/or mature B cell migration, differentiation and activation.  CD185 is a potential candidate for cell-cell interaction and activation of mature B lymphocytes in lymphatic tissues. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD185 IN INTACT ANIMAL

The expression and possible role in Burkitt's lymphoma makes CD185 and its ligand a possible therapeutic target.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD185: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD185: No information.

ADDITIONAL INSIGHTS

For further information see Dobner, T. et al (1992) Eur. J. Immunol. 22: 2795-2799.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 643P32302
Antibodies

Revised June 25, 2008


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