CD186 CXCR6 (chemokine [C-X-C motif] receptor 6) (* See
available information under CD CKR), BONZO, STRL33, TYMSTR, CDw186
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 3 glycoprotein, 7 span
B Cell
Th1 Cell
NK Cell
T Cell
Lymphoid Cell
Spleen
Small intestine
Thymus
39 / 39

Expression
CD186 is expressed in lymphoid tissues, activated T cells and on subsets of B, NK and T cells (Th1) but not Th2 cells.  Expression is in spleen, thymus, small intestine and in a lesser extent in periupheral blood leukocytes, protstate, colon and placenta.

Structure
MOLECULAR FAMILY NAME: Belongs to the chemokine receptor family.

CD186 is a multi-pass type-3, 7 span 342 aa glycoprotein.  It contains an extracellular domain which contains a single site for N-glycosylation at 16aa in the 32 aa first N-terminal extracellular region, 7 transmembrane-spanning domains and a cytoplasmic carboxyl terminal domain.  CD186 is a chemokine receptor which is G-protein coupled receptors which form a division of the leukocyte chemoattractant subfamily which is part of the rhodopsin family of GPCRs.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD186

CD186 binds the chemokine CXCL16 and is a coreceptor of strains HIV-1, HIV-2 and the monkey virus SIV.


Function
CD186 acts as the cellular receptor for the CXCL16 chemokine.  CD186 functions as a G-coupled receptor. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD186 IN INTACT ANIMAL
 
CD186 is used as a co-receptor by SIVs and by strains of HIV-1 and HIV-2 infection and is probably important in the recruitment of activated T cells to the sites of inflammation such as rheumatoid joints and inflamed livers.  The new chemokine receptor CD186 (BONZO/CXCR6) may be important in the trafficking of effector T cells that mediate type 1 inflammation, making it a potential target for therapeutic modulation of inflammatory diseases. 

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD186: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD186: No information.

ADDITIONAL INSIGHTS

For further information see Kim, C. H. et al (2001) J. Clin. Invest. 107: 595-601.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene10663O00574
Antibodies

Revised June 25, 2008


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