|CD186|| CXCR6 (chemokine [C-X-C motif] receptor 6) (* See|
available information under CD CKR), BONZO, STRL33, TYMSTR, CDw186
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 3 glycoprotein, 7 span
|39 / 39|
|CD186 is expressed in lymphoid tissues, activated T cells and on subsets of B, NK and T cells (Th1) but not Th2 cells. Expression is in spleen, thymus, small intestine and in a lesser extent in periupheral blood leukocytes, protstate, colon and placenta.|
|MOLECULAR FAMILY NAME: Belongs to the chemokine receptor family.|
CD186 is a multi-pass type-3, 7 span 342 aa glycoprotein. It contains an extracellular domain which contains a single site for N-glycosylation at 16aa in the 32 aa first N-terminal extracellular region, 7 transmembrane-spanning domains and a cytoplasmic carboxyl terminal domain. CD186 is a chemokine receptor which is G-protein coupled receptors which form a division of the leukocyte chemoattractant subfamily which is part of the rhodopsin family of GPCRs.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD186|
CD186 binds the chemokine CXCL16 and is a coreceptor of strains HIV-1, HIV-2 and the monkey virus SIV.
|CD186 acts as the cellular receptor for the CXCL16 chemokine. CD186 functions as a G-coupled receptor. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD186 IN INTACT ANIMAL
CD186 is used as a co-receptor by SIVs and by strains of HIV-1 and HIV-2 infection and is probably important in the recruitment of activated T cells to the sites of inflammation such as rheumatoid joints and inflamed livers. The new chemokine receptor CD186 (BONZO/CXCR6) may be important in the trafficking of effector T cells that mediate type 1 inflammation, making it a potential target for therapeutic modulation of inflammatory diseases.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD186: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD186: No information.
For further information see Kim, C. H. et al (2001) J. Clin. Invest. 107: 595-601.
Database accession numbers
Revised June 25, 2008