CD45R0 T200 Restricted, UCHL-1, See  antigen reactivity and See CD45
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
B Cell
T Cell
Monocyte
Cortical Thymocyte
Granulocyte
Macrophage
Dendritic Cell
180 / 180

Expression
CD45R0 is expressed on activated/memory T cells, B and dendritic cell subsets, monocytes, granulocytes, macrophages and cortical thymocytes.

Structure
MOLECULAR FAMILY NAME:


MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD45R0: No information.

Function
CD45R0 binds CD22 and is an isoform of CD45 but containing none of the A, B, or C exons.  CD45R0 is a critical requirement for TCR and BCR mediated activation and is a possible requirement for receptor-mediated activation in other leukocytes.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD45R0 IN INTACT ANIMAL: No imnformation.

Comments
MOLECULAR INTERACTION-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD45R0: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD45R0: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 5788
Antibodies
GC42A   View Reactivity
GC44A   View Reactivity
UCHL1   View Reactivity

Revised June 25, 2008


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