CD192 CCR2 (chemokine [C-C motif] receptor 2) (*See available information under CD CKR), MCP-1-R ( monocyte chemoattractant protein 1 receptor), CKR2
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 3 glycoprotein, 7 span
Monocyte
Muscle, Smooth
B Cell
Endothelial Cell
Basophil
Dendritic Cell
T Cell
NK Cell
Macrophage
42 / 42

Expression
CD192 is expressed on monocytes, basophils, smooth muscle cells, macrophages and endothelial cells.  Expression is on subsets of dendritic cells, activated T and B cells and on activated NK cells.

Structure
MOLECULAR FAMILY NAME: Belongs to the chemokine receptor family.

CD192 is a multi-pass type-3, 7 span 374 aa glycoprotein.  It contains an extracellular domain which contains a 42 aa first N-terminal region and contains the only N-glycosylation site, 7 transmembrane-spanning domain and a cytoplasmic carboxyly terminal domain.  CD192 is a chemokine receptor which are G-protein coupled receptors which forms a division of the leukocyte chemoattractant subfamily which is part of the rhodopsin family of GPCRs.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION

CD192 contains a N-glycosylation site and multiple potential phosphorylation sites.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD192

CD192 associates with MCP-1 and is a coreceptor for HIV-1.

Function
CD192 acts as the receptor for the MCP-1, MCP-3 and MCP-4 chemokines.  CD192 encodes two isoforms of a receptor for monocyte chemoattractant protein-1 (MCP-1), a chemokine.  The binding of CD192 with the ligand MCP-1 mediates a calcium flux which leads to chemotactic responses.  The receptors encoded by this gene mediate against dependent calcium mobilization and inhibition of adenyly cyclase.  Apart from the chemotactic effects of the ligand on monocytes, the receptor is expressed by B cells and activated T cells and may be expected to activate chemotactic responses in these cells.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD192 IN INTACT ANIMAL

The ligand MCP-1 of CD192 attracts monocytes to sites of inflammation and is thought to have a role in localizing inflammatory conditions such as in involved joints in rheumatoid arthritis.  It may be an important component of monocyte invasion of artery walls in athercosclerosis.  CD192 is an alternative coreceptor with CD4 for HIV-1 infection and this reaction may have therapeutic potential.  Animal models have suggested a major role for CD192 and its ligand in multiple sclerosis, but human studies have so far not confirmed this.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD192: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD192: No information.

ADDITIONAL INSIGHTS

For further information see Frade, J. M. et al (1997) J. Immunol. 159: 5576-5584.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 1231P41597
Antibodies

Revised June 25, 2008


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