CD193 CCR3 (chemokine [C-C motif] receptor 3) (*See available information under CD CKR), CKR3
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 3 glycoprotein, 7 span
Eosinophil
T Cell
Basophil
Dendritic Cell
Microglia
Epithelial Cell
41 / 41

Expression
CD193 is expressed on eosinophils, basophils, microglia and subsets of T cells and dendritic cells.  Expression is detected in TH1 and TH2 cells as well as in airway epithelial cells.     Expression is low on neurophils and monocytes.

Structure
MOLECULAR FAMILY NAME: Belongs to the chemokine receptor family.

CD193 is a multi-pass type-3, 7 span 355 aa glycoprotein.  It contains an extracellular domain which contains a 34 aa first N-terminal sequence with no N-glycosylation sites, unlike many of the other chemokine receptors,  7 transmembrane-spanning domain and a cytoplasmic carboxyl terminal domain.  CD193 is a chemokine receptor which are G-protein coupled receptors which form a division of the leukocyte chemoattractant subfamily which is part of the rhodopsin family of GPCRs.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

CD193 is predicted to be acidic in the N-terminal region and has conserved cysteines in the N-terminal segment and third extracellular loop.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD193

CD193 associates with CCL11 (Eotaxin), MCP-4, MCP-3 and RANTES.  It also functions as a coreceptor for HIV-1.

Function
CD193 is a C-C chemokine receptor and binds to eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13) and RANTES (CCL5).  CD193 binds eotaxin and the functions relect the activities of the ligand.  Exotaxin is a chemattractant for eosinophils and basophils.  CD193 transduces a signal by increasing the intracellular calcium ions level.  CD193 is involved in leukocyte chemotaxis.  CD193 as well as CD191 (CCR1) seems to regulate interaction of T cells and dentritic cells in the process of antigen presentation.  

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD193 IN INTACT ANIMAL

The function of the ligand and the cell distribution of CD193, being expressed on basophils, eosinophils and the T cell subset makes IL-4 and IL-5 (which promote allergic reactions), make it potentially a central agent in allergic reactions.  It appears to be involved in accumulation and activation of eosinophils in the airways in allergic lung disease and is a potential therapeutic target and antagonists of the pathway has been synthezied.  CD193 is useful marker for Th2 cells in monitoring immune responses.  CD193 is an alternative coreceptor with CD4 for HIV-1 infection.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD193: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD193: No information.

ADDITIONAL INSIGHTS

For further information see Sato, K. et al (1999) Blood 93: 34-42.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 1232P51677
Antibodies

Revised June 25, 2008


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