|CD196||CCR6 (chemokine [C-C motif] receptor 6) (*See available information under CD CKR), CKR6, LARC receptor|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 3 glycoprotein, 7 span
|42 / 42|
|CD196 is expressed on B cells, Langerhans cells and subsets of T cells, immature dendritic cells and also on memory T cells but not on natural killer cells, monocytes or granulocytes. Expression is selective in tissue by marginal zone and follicular mantel B cells. Expression is found in spleen, lymph nodes, appendix and fetal liver. Selective expression by a subset of non-Hodgkin's lymphomas is associated with mucosal tissue.|
|MOLECULAR FAMILY NAME: Belongs to the chemokine receptor family.|
CD196 is a multi-pass type-3, 7 span 374 aa glycoprotein. It contains an extracellular domain which contains a 47 aa N-terminal and 2 potential N-glycosylation sites, a 7 transmembrane-spanning domain and a cytoplasmic carboxyl terminal domain. CD196 is a chemokine receptor which are G-protein coupled receptors which forms a division of the leukocytes chemoattractant subfamily which is part of the rhodopsin family of GPCRs.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD196|
The ligand of CD196 is MIP-3α (CCL20) and LARC. CD196 binds the β-defensin, a family of anti-bacterial peptides.
|CD196 is a receptor for C-C type chemokine and binds with the macrophage inflammatory protein (MIP-3α) and LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. It is suggested that CD196 and MIP-3α may play a role in the physiology of resting memory T cells and in the interactions of memory T cell, B cells and dendritic cells. CD196 has been shown to be important for B-lineage maturation and antigen-driven B cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Interaction with β defensins suggests a role in immune response to bacterial infection. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD196 IN INTACT ANIMAL
CD196 is a coreceptor for HIV-1 infection. CD196 is involved in mucosal immunity. The selective expresssion of CD196 by mucosa-associated non-Hodgkin's lymphoma has a potentail diagnostic value and the interaction between the receptor and its ligand may provide a therapeutic target in these malignancies.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD196: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD196: No information.
For further information see Liao, F. et al (1999) J. Immunol. 162: 2186-2194.
Database accession numbers
Revised June 25, 2008