CD196 CCR6 (chemokine [C-C motif] receptor 6) (*See available information under CD CKR), CKR6, LARC receptor
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 3 glycoprotein, 7 span
B Cell
Dendritic Cell
Langerhans Cell
T Cell
Liver
Lymph Node
Spleen
42 / 42

Expression
CD196 is expressed on B cells, Langerhans cells and subsets of T cells, immature dendritic cells and also on memory T cells but not on natural killer cells, monocytes or granulocytes.  Expression is selective in tissue by marginal zone and follicular mantel B cells.  Expression is found in spleen, lymph nodes, appendix and fetal liver. Selective expression by a subset of non-Hodgkin's lymphomas is associated with mucosal tissue.

Structure
MOLECULAR FAMILY NAME:  Belongs to the chemokine receptor family.

CD196 is a multi-pass type-3, 7 span 374 aa glycoprotein.  It contains an extracellular domain which contains a 47 aa N-terminal and 2 potential N-glycosylation sites, a 7 transmembrane-spanning domain and a cytoplasmic carboxyl terminal domain.  CD196 is a chemokine receptor which are G-protein coupled receptors which forms a division of the leukocytes chemoattractant subfamily which is part of the rhodopsin family of GPCRs.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD196

The ligand of CD196 is MIP-3α (CCL20) and LARC.  CD196 binds the β-defensin, a family of anti-bacterial peptides.

Function
CD196 is a receptor for C-C type chemokine and binds with the macrophage inflammatory protein (MIP-3α) and LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.  It is suggested that CD196 and MIP-3α may play a role in the physiology of resting memory T cells and in the interactions of memory T cell, B cells and dendritic cells.  CD196 has been shown to be important for B-lineage maturation and antigen-driven B cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses.  Interaction with β defensins suggests a role in immune response to bacterial infection.  

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD196 IN INTACT ANIMAL

CD196 is a coreceptor for HIV-1 infection.  CD196 is involved in mucosal immunity.  The selective expresssion of CD196 by mucosa-associated non-Hodgkin's lymphoma has a potentail diagnostic value and the interaction between the receptor and its ligand may provide a therapeutic target in these malignancies.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD196: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD196: No information.

ADDITIONAL INSIGHTS

For further information see Liao, F. et al (1999) J. Immunol. 162: 2186-2194.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 1235P51684
Antibodies

Revised June 25, 2008


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