CDw198 CCR8 (chemokine C-C motif receptor 8) (*See available information under CD CKR), CKR-L1
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 3 glycoprotein, 7 span
T Cell
Monocyte
Th2 Cell
Dendritic Cell
NK Cell
Thymus
Spleen
42 / 42

Expression
CDw198 is expressed on monocytes, dendritic cells and T cell subsets but not in peripheral blood lymphocytes or neutrophils.  Expression is high on NK cells, Th2 cells and in spleen and thymus. 

Structure
MOLECULAR FAMILY NAME:  Belongs to the chemokine receptors family.

CDw198 is a multi-pass type-3 7 span 355 aa glycoprotein.  It contains a 35 aa extracellular domain which contains N- terminal sequence but has no N-glycosylation sites, 7 transmembrane-spanning domains and a 51 aa cytoplasmic carboxyl C-terminal domain.  CDw198 is a chemokine receptor which are G-protein coupled receptors which forms a division of the leukocyte chemoattractant subfamily which is part of the rhodopsin family of GPCRs. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CDw198

CDw198 binds chemokine SCYA1/1-30 and functions as a coreceptor with CD4 for HIV-1.


Function
Chemokines and their receptors mediate the function of chemokines which have several roles as inducers of cell movement and activation.  They are important for the migration of various cell types into the inflammatory sites.  The receptor proteins are shown to signal in response to the human CC chemokine I-309.  Identification of CC chemokines thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 β (MIP-1β) are named CCR8 ligands, as they induce chemotaxis in CCR8   Jurkat stable transfectants.  CDw198 is the receptor for the chemokine SCYA1/I-309 (otherwise known as CCL1), interaction is thought to play an important role to regulate monocyte chemotaxis and thymocyte apoptosis and plays a role in the allergen-induced recruitment of Th2 cells.  Knockout mice showed deficiency in the Th2 arm of the immune system, including deficits in the Th2 cytokine (principally IL-4. IL-5 and IL-13) production and reduced eosinophil responses in vitro and in vivo.  The receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues.  CDw198 may regulate monocyte chemotaxis and thymic cell line apoptosis and may regulate activation, migration and proliferation of lymphoid cells. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CDw198 IN INTACT ANIMAL

CDw198 is an alternative co-receptor with CD4 for HIV-1 infection. 


Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CDw198: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CDw198: No information.

ADDITIONAL INSIGHTS

For further information see Bernardini, G. et al (1998) Eur. J. Immunol. 28: 582-588.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 1237P51685
Antibodies

Revised June 25, 2008


Contact us: Webmaster |  509-335-9515 | Accessibility | Copyright | Policies
College of Veterinary Medicine Washington State University, Pullman, WA, 99164-7010 USA
Copyright 1995-2003 Washington State University