CDw199 CCR9 (chemokine C-C motif receptor 9) (*See available information under CD CKR)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 3 glycoprotein, 7 span
T Cell
Thymocyte
IEL
Melanoma Cell
Thymus
49 / 49

Expression
CDw199 is expressed on memory T cell subsets.  Expression is on thymocytes, IEL, melanoma cells, and lamina propria mononuclear cells.  The expression is high in the thymus but low in lymph nodes, bone marrow and spleen.

Structure
MOLECULAR FAMILY NAME:  Belongs to the chemokine receptor family.

CDw199 is a multi-pass type-3 7 span 369 aa glycoprotein.  It contains an extracellular domain, 7 transmembrane-spanning domains and a cytoplasmic carboxyl terminal domain.  CDw199 is a chemokine receptor which are G-protein coupled receptors which form a division of the leukocyte chemoattractant subfamily which is part of the rhodopsin family of GPCRs.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CDw199

CDw199 binds the chemokine SCYA25 know as TECK or CCL25.

Function
Chemokines and their receptors mediate the functions of chemokines which have several roles as inducers of cell movement and activation and  are key regulators of the thymocytes migration and maturation in normal and inflammation conditions.  CDw199 is the receptor for chemokine SCYA25/TECK.  Binding of the ligand leads to an elevation of cytosolic calcium 2+ level which leads to chemotactic response to the ligand and it transduces a signal by increasing the intracellular calcium ions level.  CDw199 is thought to have roles in T cell development and cell migration as well as in intestinal immune responses.  CDw199 appears to confer homing properties to the small intestine on memory T cells.  It has been found that CDw199 is differently expressed by T lymphocytes of the small intestine and colon, suggesting a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segments of the gastrointestinal tract.  The thymus-expressed chemokine (TECK) is a specific agonist for a human organ receptor called GPR-9-6.  It was proposed that GPR-9-6 be renamed as CC chemokine receptor 9 (CCR9), thus CDw199. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CDw199 IN INTACT ANIMAL

CDw199 is an alternative coreceptor with CD4 for HIV-1 infection.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CDw199: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CDw199: No information.

ADDITIONAL INSIGHTS

 For further information see Zaballos, A. et al (1999) J. Immunol. 162: 5671-5675.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene10803P51686
Antibodies

Revised June 25, 2008


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