CD218a IL18R1 (interleukin 19 receptor 1), IL1RRP, CDw218a,
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Neutrophil
Lymphocyte
Dendritic Cell
B Cell
NK Cell
Endothelial Cell
Monocyte
Granulocyte
Leukocyte
Lung
Spleen
Thymus
Liver
Prostate
Small intestine
Colon
Placenta
Heart
Myeloid Cell
T Cell
Gut
62 / 62

Expression
CD218a, formally CDw218a,  is expressed on lymphocytes, neutrophils, monocytes, granulocytes, endothelial and NK cells.  Expression is on subsets of B, T, myeloid and dendritic cells.  Expression is in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, gut, placenta, colon, and heart, and is absent from brain, skeletal muscle, pancreas and kidney.  A high level of expression is found in Hodgkin's disease cell lines.

Structure
MOLECULAR FAMILY NAME: Belongs to the interleukin-1 receptor family.

CD218a is a single-pass type-1 523 aa glycoprotein.  It contains an 18 signal sequence, an extracellular domain which contains 3 Ig-like C2-type domains  and 8 potential N-glycoslayation sites, a 21 aa transmembrane and an 191 cytoplasmic domain which includes a TIR (Toll/IL-1 receptor-like) homologous region which are involved in interaction with cellular signaling molecules.  

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD218a

CD218a and CD218b function together as the IL-18 receptor.  CD218a is the ligand-binding chain.

Function
CD218a and CD218b binds IL-18 and mediates the activities of IL-18 through the activation of NF-κB.  It is a proinflammatory cytokine that works in concert with IL-12 and promotes Th1 and Th2 immune responses and also induces IFN-γ production and activates NK cells.  The protein encoded by CD218a is a cytokine receptor that belongs to the IL-1 receptor family but does not bind IL-1α or IL-1β.  The receptor specifically binds IL-18 and is essential for IL-18 to mediate signal transduction.  CD218a is a heterodimer consisting of a ligand-binding α chain, and is an associating β chain.  IFN-α and IL-12 are reported to induce the expression of this receptor in NK and T cells.  

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD218a IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD218a: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD218a: No information.

ADDITIONAL INSIGHTS

For further information see Torigoe, K. et al (1997) J. Biol. Chem. 272: 25737-25742.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 8809Q13478
Antibodies

Revised June 25, 2008


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