CD218b IL18RAP (interleukin 18 receptor accessory protein), 
CDw218b
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
T Cell
68 / 68

Expression
CD218b, formally CDw218b, expression is less certain but it appears to show a more selective distribution, being seen on activated but not resting helper T cells.

Structure
MOLECULAR FAMILY NAME:  Belongs to the interleukin-1 receptor family.

CD218b is a single-pass type-1 580 aa glycoprotein.  It contains a 19 aa signal peptide, a 342 aa extracellular domain containing 2 Ig-like C2-type segment and 4 potential N-glycosylation, a 21 aa transmembrane domain and a 222 aa cytoplasmic domain which contains a TIR (Toll/IL-1 receptor-like) homologous region.  The receptor complex for IL-18 is not yet well characterized.  The protein encoded by CD218b is an accessory subunit of the heterodimic receptor for IL-18. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD218b

CD218b and CD218a binds togerther as the IL-18 receptor.


Function
CD218a and CD218b binds IL-18 and mediates the activities of IL-18 through the activation of NF-κB.  It is a proinflammatory cytokine that works in concert with IL-12 and promotes Th1 and Th2 immune responses and also induces IFN-γ production and activates NK cells.  CD218b is a proinflammatory cytokine that works in concert with IL-12 and promotes both Th1 and Th2 immune responses and induces IFN-γ production and activates NK cells.  CD218b enhances the IL-18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of the IL-18 receptor.  Together with IL18R1, it probably belongs to the IL-18 receptor complex but it seems not to interact directly with IL-18.  The coexpression of IL18R1 and CD218b is required for the activation of NF-κB and MAPK8 (JNK) in response to IL-18.  CD218b is a heterodimer consisting of a ligand-binding α chain, and an associating β chain.  Forming a heterodimeric with IL-18Rα enhances IL-18 binding.  CD218b is involved in signal transduction.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD218b IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD218b: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD218b: No information.

ADDITIONAL INSIGHTS

For further information see Torigoe, K. et al (1997) J. Biol. Chem. 272: 25737-25742.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 8807O95256
Antibodies

Revised June 25, 2008


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