TNFSF14 (tumor necrosis factor ligand superfamily member 14), HVEML (herpes virus entry mediator ligand), LIGHT
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 2 glycoprotein
|29 / 29|
CD258 is expressed on activated T cells, monocytes and dendritic cells derived by in vitro culture but not by dendritic cells isolated fresh from blood. Expression is predominantly in the spleen and brain. Low expression is in resting blood and tissue leukocytes and is upregulated on activation. Weak expression is on peripheral lymphoid tissues, heart, placenta, liver, lung, appendix, and kidney but no expression is seen in fetal tissues, endocrine glands, nonhematopoietic tumor lines and most cancer cell lines do not express CD258.
|MOLECULAR FAMILY NAME: Belongs to the tumor necrosis factor superfamily.|
CD258 is a single-pass type-2 240 aa glycoprotein. It contains an 181 aa extracellular domain which contains 1 N-glycosylation site, a 22 aa transmembrane domain and a 37 aa N-terminal cytosolic cytoplasmic domain.
Alternative splicing yields 2 different isoforms. The soluble form of isoform 1 is derived from the membrane form by proteolytic processing and is secreted. Isoform 2 is cytoplamic.
CD258 is N-glycosylated.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD258 |
CD258 binds two receptors both members of the TNF receptor family, CD270 (HVEM) and LTbR.
|Redundnacy in function and receptor binding in the TNF family makes it difficult to work out the physiological function of each member. CD258 is the ligand for herpes virus entry mediator (TNFRSF14), lymphotoxin β receptor and decoy receptor 3 (DcR3/TR6). CD258 can trigger apoptosis in tumor cells as well as cell activation by signaling through TRAF3. This protein has a role in the immune system and can act as a costimulatory for stimulating T cell proliferation and cytokine secretion preferentially TH1 cytokines. The protein is also reported to prevent tumor necrosis factor α mediated apoptosis in primary hepatocyte. CD258 induces activation of dendritic cells, indicated by upregulation of costimulatory and adhesion molecules and increased antigen presentation. It is also thought to play a role in the maturation of dendritic cells and the regulation of apoptosis. CD258 also appears to function in thymic repertoire selection and in aspects of the inflammatory response. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION WHICH REGULATE TRANSCRIPTION OF CD258
The protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD258: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD258: No information.
For further information see Wang, J. et al (2001) J. Clin. Invest. 108: 1771-1780.
Database accession numbers
Revised June 25, 2008