CD252 

TNFSF4 (tumor necrosis factor receptor ligand superfamily, member 4), OX40L, CD134L

Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
Dendritic Cell
Endothelium
B Cell
Mast Cell
Monocyte
Thymus
Spleen
Heart
T Cell
Leukemia cell
34 / 34

Expression

CD252 is expressed on  antigen presentation cells including B cells, dendritic cells, mast cells and endothelium.  Expression is also on cardiac monocytes and human T cell leukemia virus type 1 cells.  There is also expression in the human spleen, thymus and heart.



Structure
MOLECULAR FAMILY NAME: Belongs to the tumor necrosis factor superfamily.

CD252 is a single-pass type-2 183 aa glycoprotein.  It contains a 133-residue extracellular domain which contains 4 potential  N-glycosylation sites, a transmembrane domain and a cytoplasmic domain.

MOLECULAR MASS

The molecular weight that was predicted to be 21 kDa and was observed to be 34 kDa.

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.



Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD252

CD252 is a ligand for CD134 (TNFRSF4/OX40).


Function
The protein encoded by CD252 is a cytokine that belongs to the TNF ligand family.  CD252, a membrane-expressed cytokine, can act as costimulator through interaction with its ligand on T cells.  CD252 interaction co-stimulates T cell activation, proliferation and cytokine production.  This cytokine is a ligand for receptor CD134.  In surface Ig- and CD40 (OX40)- stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells.  CD40 on T cells can adhere to CD252 on vascular endothelium. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD252 IN INTACT ANIMAL

CD252 is expressed in psoriatic skin and airways muscle and may be a therapeutic target in psoriasis and asthma.  The gene is polymorphic, but so far no associations have been reported with disease severity.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD252: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD252: No information.

ADDITIONAL INSIGHTS

For further information see Kotani, A. et al (2002) Immunol. Lett. 84: 1-7.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 7292P23510
Antibodies

Revised June 25, 2008


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