|CD256||TNFSF13 (tumor necrosis factor ligand superfamily member 13), TALL2, APRIL|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|28 / 28|
|CD256 is not generally seen as a membrane protein because it is secreted after intracellular proteolysis. mRNA is expressed on monocytes, macrophages, leukocytes and myeloid cells. High levels of expression are in transformed cell lines, cancer of colon, some tumors, thyroid, and lymphoid tissues. Expression is downregulated by mitogens. Expression is seen on the pancreas and colon but there is weak expression in prostate and peripheral blood leukocytes. CD256 is a heterotrimer with CD257 and is associated with inflammatory autoimmune disease.|
|MOLECULAR FAMILY NAME: Belongs to the tumor necrosis factor superfamily.|
CD256 is a single-pass type-2 250 aa secreted glycoprotein. It contains no signal sequence, a 201 aa extracellular domain which contains 1 N-linked glycosylation site and is secreted as a result of intracellular proteolysis in the Golgi, a 20 aa hydrophobic transmembrane region and a 28 aa N-terminal cytoplasmic domain. CD256 is predicted to form homotrimers and can form a heterotrimer with CD257.
Alternative splicing yields 3 different isoforms.
CD256 has 1 N-linked glycosylation site.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD256|
CD256 binds CD269 and CD267.
|CD256, a member of TNF, promotes T, and B cell proliferation by binding to B cell maturation antigen CD269 (BCMA) and CD267 (TACI) receptors. CD256 has a role in B cell development through interaction with CD269 and may additionally induce apoptosis throught interaction with other TNFRSF members such as CD95 and CD268. It may have a role in controlling the regulation of tumor cell growth, in the function in the nervous system and acts as a growth factor for glioblastoma cell lines. It may be involved in monocyte/macrophage mediated immunological processes. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD256 IN INTACT ANIMAL
It has been proposed that CD256 regulates B-cell as well as T-cell function and has pro-and anti-inflammatory effects in rheumatoid arthritis and other autoimmune diseases. CD256 may have a role in controlling the regulation of tumor cell growth, in the function in the nervous system and acts as a growth factor for glioblastoma cell lines.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD256: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD256: No information.
For further information see Roschke, V. et al (2002) J. Immunol. 169: 4314-4321.
Database accession numbers
Revised June 25, 2008