|CD257||TNFSF13b (tumor necrosis factor ligand superfamily member 13b), BLyS (B lymphocyte stimulator), BAFF, TALL1|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 2 glycoprotein
|31 / 31|
|CD257 is expressed on dendritic cells, activated monocytes, B lymphocytes, macrophages, and myeloid cells. Expression is in peripheral blood leukocytes, spleen, lymph node, bone marrow and T cells. Lower expression is seen in non-lymphoid tissues such as placenta, heart, lung, and in fetal liver, thymus and pancreas. Serum soluble CD257 is elevated in patients with autoimmune inflammatory conditions and in multiple myeloma and expression is found to be upregulated by IFN-γ.|
MOLECULAR FAMILY NAME: Belongs to the tumor necrosis factor lsuperfamily.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD257|
CD257 binds to CD269, CD267 and CD268.
|The protein encoded by CD257 is a cytokine belonging to the TNF ligand family. This cytokine is a ligand for receptors CD267 (TNFRSF13B/TACI), CD269 (TNFRSF17/BCMA), and CD268 (TNFRSF13C/BAFFR). This cytokine is expressed in B cell lineage cells and acts in B cell survival, activation and differentiation of death of B cells. It is involved in the growth factor and costimulator of Ig production. There is resistance to apoptosis on some B cell tumors including CLL. A biologic response is observed only among B cells due to their expression of the specific receptor. CD257 is also involved as a costimulator in T-B cell interactions. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD257 IN INTACT ANIMAL
The critical role of CD257 in B-cell survival and activation, including its role in B-cell tumor survival, has made it a target for therapeutic applications. Soluble CD257 retains the ability to activate cells, unlike many TNF family members, which are active only in membrane-expressed form.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD257: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD257: No information.
For further information see Moore, P. A. et al (1999) Science 285: 260-263.
Database accession numbers
Revised June 25, 2008