|CD259||NGF (nerve growth factor, β polypeptide), HSANS, β-NGF|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|MOLECULAR FAMILY NAME: Belongs to the nerve growth factor family.|
CD259 encodes a secreted protein. It contains 2 identical 118 aa β-chains which are responsible for nerve growth stimulating activity.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD259 No information.|
|CD259 encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and is important for the development and maintenance of the sympathetic and sensory neurons systems. CD259 is involved in the regulation of growth and stimulates division and the differentiation of sympathetic and certain embryonic sensory neurons.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD259 IN INTACT ANIMAL
Mutations in CD259 have been associated with hereditary sensory and autonomic neuropathy (HSANS) and dysregulation of this gene's expression is associated with allergic rhinitis.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD259: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD259: No information.
Database accession numbers
Revised June 25, 2008