CD259 NGF (nerve growth factor, β polypeptide), HSANS, β-NGF
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Secreted protein

Expression

 



Structure
MOLECULAR FAMILY NAME: Belongs to the nerve growth factor family.

CD259 encodes a secreted protein.  It contains 2 identical 118 aa β-chains which are responsible for nerve growth stimulating activity.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD259 No information.

Function
CD259 encodes a secreted protein which homodimerizes and is incorporated into a larger complex.  This protein has nerve growth stimulating activity and is important for the development and maintenance of the sympathetic and sensory neurons systems. CD259 is involved in the regulation of growth and stimulates division and the differentiation of sympathetic and certain embryonic sensory neurons.


BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD259 IN INTACT ANIMAL

Mutations in CD259 have been associated with hereditary sensory and autonomic neuropathy (HSANS) and dysregulation of this gene's expression is associated with allergic rhinitis.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD259: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD259: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 4803P01138
Antibodies

Revised June 25, 2008


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