CD261 TNFRSF10a (tumor necrosis factor receptor superfamily, member 10a), TRAIL-R1, DR4
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Tumor Cell
Breast
T Cell
Peripheral blood
Small intestine
Thymus
Carcinoma Cell
Erythroleukemia cell
Gut
50 / 50

Expression
CD261 is widely expressed.  High levels of expression are found on some tumor cells, lymphoid and gut tissues, activated T cells, peripheral blood leukocytes, small intestine, thymus, K562 erythroleukemia cells amd MCF7 breast carcinoma cells and very weak on leukocyte cells. 

Structure
MOLECULAR FAMILY NAME: Belongs to the tumor necrosis factor receptor family.

CD261 is a single-pass type-1 468 aa glycoprotein.  It contains a 23 aa signal sequence, a 216 aa extracellular domain containing 3 TNFR cysteine-rich repeats and 1 potential N-glycosylation site, a 23 aa transmembrane domain and a 206 aa cytoplasmic domain containing a intracellular death domain.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD261

CD261 binds CD253 (TNFSF10).

Function
CD261 acts as a ligand for CD253 (TRAIL).  CD261 contains a cytoplasmic death domain (DR4), which mediates the apoptosis of sensitive cells via the adaptor molecule FADD and caspase-8.  FADD binds DR4 and recruits caspase-8, which initates a sequence of events that leads ro cell death.  This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand CD253 and thus transduces cell death signal and induces cell apoptosis.  

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD261 IN INTACT ANIMAL

A polymorphism in CD261 has been associated with the risk of bladder cancer.

Comments
MOLECULAR INTERACTIONS-
PROTEIN AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD261: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD261: No information.

ADDITIONAL INSIGHTS

For further information see Griffith, T. S. et al (1999) J. Immunol. 162: 2597-2605.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEnrezgene 8797O00220
Antibodies

Revised June 25, 2008


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