CD262 TNFRSF10b (tumor necrosis factor receptor superfamily, member b), TRAIL-R2, DR5
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Broad
Leukocyte
Tumor Cell
Ovary
Stomach
Spleen
Thymus
Pancreas
Prostate
Liver
Heart
Placenta
Lung
48 / 48

Expression
CD262 expression is broad.  Expression is wide in adult and fetal tissues and high in tumor cell lines.  High expression is in lymphoid tissue, lung, peripheral blood leukocytes, pancreas, spleen, thymus, prostate, ovary, heart, placenta, uterus, testis, esophagus, stomach, intestine and liver but is not detected in the brain.  Expression is induced by tumor suppressor p53.  

Structure
MOLECULE FAMILY NAME: Belongs to the tumor necrosis factor receptor superfamily.

CD262 is a single-pass type-1 440 aa glycoprotein.  It contains 55 signal sequence, an 155 aa extracellular domain containing 3 TNFR cysteine-rich repeats but lacks N-glycosylation sites, a 21 aa transmembrane domain and a 209 cytoplasmic domain which contains an intracellular death domain.
 
MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCATED WITH CD262

CD262 binds to CD253 (TRAIL, TNFS10).

Function
CD262 acts as a ligand for CD253 (TRAIL) and contains a cytoplasmic death domain, which mediates the apoptosis of sensitive cells via the adaptor molecule FADD and caspase-8.  The receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand CD253 and transduces apoptosis signal.  Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein and FADD recruits caspase-8 to the activated receptor.  Activation of NF-κB is promoted.  CD262 is regulated by the tumor suppressor p53. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD262 IN INTACT ANIMAL

Defects in CD262  may be a cause of squamous cell carcinoma of the head and neck.



Comments
MOLECULAR INTERACTIONS-
PROTEIN AND DNA ELEMENTS WHICH REGULATE TRANSCIPTION OF CD262: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD262: No information.

ADDITIONAL INSIGHTS

For further information see Griffith, T. S. et al (1999) J. Immunol. 162: 2597-2605.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 8795O14763
Antibodies

Revised June 25, 2008


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