CD269 TNFRSF17 (tumor necrosis factor receptor superfamily, member 17), BCMA, BCM
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 3 glycoprotein
B Cell
Plasma Cell
27 / 27

Expression
CD269 is expressed in mature and perinuclear B cells and plasma cells, plasmablasts and tonsillar germinal center B cells but not in T cells or monocytes.  CD269 has low surface density and most remains intracellular where it is associated with peri-nuclear Golgi-like structures.
 

Structure
MOLECULAR FAMILY NAME: Belongs to the tumor necrosis factor receptor family.

CD269 is a single-pass type-3 184 aa glycoprotein.  It contains a 23 aa signal sequence, a 54 aa extracellular domain which contains a TNFR Cys repeat, a transmembrane domain and a 107 aa cytoplasmic domain which has a conserved motif of 6 cysteines in the N-terminal region and TRAFs1, 2, 3, 5 and 6.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD269

CD269 binds CD257 (TALL1) with low affinity and CD256 (TALL2) with high affinity.

Function
CD269 like CD267 (TACI), binds CD268 (BAFF) and CD256 (APRIL) promoting the differentiation and proliferation of B cells as well as B cell survival and autoimmune response and plays a role in the regulation of humoral immunity.  It is shown to bind to CD257 (TNFSF13b) and to mediate signaling leading to NF-κB and JNK activiation.  This receptor also binds various TRAF family members.  CD269 is essential for plasma cell survival and long-lived bone marrow plasma cells.  CD269-/- mice have normal serum Ig levels ande normal antibody responses but reduced numbers of long-lived bone marrow plasma cells compared to wild-type mice.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD269 IN INTACT ANIMAL

CD269 is a potential therapeutic target for selective elimination of plasma cells in the treatment of antibody-mediated autoimmunity.  A chromosomal aberration involving CD269 is found in a form of T cell acute lymphoblastic leukemia (T-ALL) involves a translocation with IL-2 gene.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD269: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD269: No information.

ADDITIONAL INSIGHTS

For further information see Madry, C. et al (1998) Int. Immunol. 10: 1693-1702.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 608Q02223
Antibodies

Revised June 25, 2008


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