|CD272||BTLA (B and T lymphocyte attenuator precursor)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|33 / 33|
|CD272 expression is induced during activation of T and B cells but expressed on Th1 cell but not on Th2 cells. Expression is on all mature lymphocytes, splenic macrophages, bone marrow-derived dendritic cells, in lymph node and spleen. |
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.|
CD272 is a single-pass type-1 259 aa glycoprotein. It contains a 30 aa signal sequence, an 127 aa extracellular domain which contains an Ig-like V-type domain and 3 potential N-linked glycosylation sites, a 21 aa transmembrane domain and an 111 aa intracellular C-terminal cytoplasmic domain which contains 2 immunoreceptor tyrosine-based inhibitory motifs (ITIMs) which is required for association with phosphatases SHP-1 and SHP-2 and a third motif which is a Grb-2 recognition consensus. Analysis demonstrated a surface expression of a transmembrane protein and showed expression of a glycosylated protein that could be phosphorylated on tyrosines in the ITIMs.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
CD272 is phosphorylated on Try residues by TNFRSF14 and by antigen receptors crosslinking, both inducing association with PTPN6/SHP-1 and PTPN11/SHP-2. CD272 is N-glycosylated.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD272|
CD272 binds CD270 (LIGHT-R, HVEM).
|CD270 ligation of CD272 induces tyrosine phosphorylation of the CD272 cytoplasmic domain, recruitment of phosphatases SHP-1 and SHP-2 and inhhibitory signaling which results in attenuation of T-cell activation. CD272 interacts with the B7 homolog 4 (B7HA). It is a lymphocyte inhibitory receptor on T lymphocytes which inhibits lymphocytes during immune response and has similarities to CD152 (CTLA-4) and CD279 (PD-1). Knockout mice have stronger B- and T-cell responses than wild-type mice and increased susceptibility to autoimmunity. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD272 IN INTACT ANIMAL: No information.
PROTEIN AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD272: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD272: No information.
For further information see Watanabe, N. et al (2003) Nat. Immunol. 4: 670-679.
Database accession numbers
Revised June 25, 2008