CD277 BTN3A1 (butyrophilin, subfamily 3, member 1), BTF5, BT3.1
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
T Cell
B Cell
Dendritic Cell
NK Cell
Monocyte
Stem Cell
Endothelial Cell
Heart
Pancreas
Lung
Liver
Placenta
Skeletal muscle
Ovary
Breast
56 / 56

Expression
CD277 is expressed on B and T cells, NK and dendritic cells, monocytes, endothelial cells and stem cell subsets.  Expression is high in heart and lung.  There is moderate expression in placenta, liver and muscle. There is high expression found in lymphoid tissues and human umbilical vein endothelial cell (HUVEC), leukemia cell lines and tumor cell lines derived from breast, ovary and pancreas.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.

CD277 is a single-pass type-1 484 aa glycoprotein.  It contains a 29 aa signal sequence, a 225 extracellular domain which contains 2 Ig-like V type domains, a 17 aa transmembrane domain and a 242 aa cytoplasmic domain which has an 170 aa B30.2-like globular domain.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.



Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD277: No information.

Function
CD277 is a member of the Butyrophilin (BT3) superfamily of the B7/BT family and has been recently described as a regulator of T cell activation and function.  CD277 is thought to play a role in the regulation of the immune response but it remains to be demonstrated.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD277 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD277: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD277: No information.

ADDITIONAL INFORMATION

For further information see Compte, E. et al (2004) Eur. J. Immunol. 34: 2089-2099.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene11119O00481
Antibodies

Revised June 25, 2008


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