|CD277||BTN3A1 (butyrophilin, subfamily 3, member 1), BTF5, BT3.1|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|56 / 56|
|CD277 is expressed on B and T cells, NK and dendritic cells, monocytes, endothelial cells and stem cell subsets. Expression is high in heart and lung. There is moderate expression in placenta, liver and muscle. There is high expression found in lymphoid tissues and human umbilical vein endothelial cell (HUVEC), leukemia cell lines and tumor cell lines derived from breast, ovary and pancreas.|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.|
CD277 is a single-pass type-1 484 aa glycoprotein. It contains a 29 aa signal sequence, a 225 extracellular domain which contains 2 Ig-like V type domains, a 17 aa transmembrane domain and a 242 aa cytoplasmic domain which has an 170 aa B30.2-like globular domain.
Alternative splicing yields 2 different isoforms.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD277: No information.|
|CD277 is a member of the Butyrophilin (BT3) superfamily of the B7/BT family and has been recently described as a regulator of T cell activation and function. CD277 is thought to play a role in the regulation of the immune response but it remains to be demonstrated.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD277 IN INTACT ANIMAL: No information.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD277: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD277: No information.
For further information see Compte, E. et al (2004) Eur. J. Immunol. 34: 2089-2099.
Database accession numbers
Revised June 25, 2008