CD286 TLR6 (Toll-like receptor 6)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Leukocyte
Monocyte
Dendritic Cell
Lung
Ovary
Endothelial Cell
85 / 85

Expression

CD286 is expressed on leukocytes, monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells, dermal microvessel endothelial cells and mRNA. Expression is in the lung, ovary and breast milk.



Structure
MOLECULAR FAMILY NAME:  Belongs to the Toll-like receptor family.

CD286 is a single-pass type-1 765 aa  glycoprotein.  It contains a 31 aa signal sequence, a 555 aa extracellular domain which contains 13 leucine-rich repeats (LRR) capped at each end by N- and C-terminal motifs and has 9 potential N-linked glycosylation sites, a 21 aa transmembrane domain and a 189 aa intracellular cytoplasmic domain containing 145 aa Toll/IL-1R domain which interacts with the adaptor molecule myeloid differentiation primary response gene 88 (MyD88).  The LRRs form a "horseshoe" shaped structure which is the ligand binding domain.  CD286 forms heterodimers with CD282 (TLR2).

MOLECULAR MASS

POST-TRANSCRIPTION MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

CD286 has 9 potential N-linked glycosylation sites.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD286

CD286/CD282 complex recognizes bacterial diacyl-lipopeptides, including mycoplasmal macrophage activating lipopeptide-2kDa (MALP-2, soluble TB factor, phenol-soluble modulin (PSM), B. burgdorferi outer surface protein A-lipoprotein (OspA-L) and group B streptococci heat labile soluble factor (GBS-F).

Function
CD286 is a Toll-like receptor and plays plays a fundamental role in pathogen recognition and activation of innate immunity by recognizing specific pathogen associated molecular patterns (PAMPs) on pathogens.  PAMPs are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.  PAMP binding of CD286/CD282 complex triggers intracellular MyD88-dependent signaling pathways and nuclear translocation of NF-κB, which ultimately leads to production of pro-inflammatory cytokines to stimulate host defences and iniate an acquired immune response. 
TLRs participate in the innate immune response to microbial agents and are highly conserved from Drosophilia to humans and share structural and functional similarities.  This receptor functionally interacts with Toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.  The receptor participates in the innate immune response to Gram-positive bacteria and fungi.  CD286 acts via MyD88 and TRAF6, leading to NF-κB activation, cytokine secretion and the inflammatory response.  CD286 binds CD282 via their respecitive extracellular domains and binds MyD88 via their respective TIR domains.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD286 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD286: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD286: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene10333Q9Y2C9
Antibodies

Revised June 25, 2008


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