CD291 TLR11 (Toll-like receptor 11)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Macrophage
Epithelium
97 / 97

Expression

CD291 is expressed on macrophages and strongly expressed by renal and bladder epithelium and weakly expressed on liver epithelium.



Structure
MOLECULAR FAMILY NAME: Belongs to the Toll-like receptor family.

CD291 is a single-pass type-1 896 aa glycoprotein.  It contains a 30 aa signal sequence,  a 691 aa extracellular domain which contains 11 leucine-rich repeats (LRR) capped at each end by N- and C-terminal motifs and contains 9 potential N-glycosylation sites, a 21 aa transmembrane domain and a 214 aa intracellular cytoplasmic domain which contains an 184 aa Toll/IL-1R domain which interacts with the adaptor molecule myeloid differentiation primary response gene 88 (MyD88).  The LRRs form a "horseshoe" shaped structure which is the ligand binding protein.  Unlike the murine CD291 gene, the human CD291 gene bears several stop codons and does not encode a full-length protein.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

CD291 has 9 potential glycosylation sites.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD291

Murine CD291 binds protozan profilin and recognizes as yet undermined ligand of human uropathogenic Escherichia coli (UPEC).

Function
A Toxoplasma gondii profilin has been established which is a CD291 ligand present in a parasite, and is an immunodominant antigen in the CD4+ T cell response to the pathogen.  The immunogenicity of profilin-like molecule from T. gondii generates a potent IL-12 response in murine dendritic cells that is entirely dependent on both CD291 recognition and signaling through the adaptor myeloid differentiation factor 88 (MyD88).  Selective responsiveness to this parasite protein is regulated at the level of antigen presentation by dendritic cells and required both TLR signaling and MHC class II recognition acting in cis.  These findings support a major influence of TLR recognition in antigen presentation by dendritic cells in vivo and establish a mechanism by which TLR ligand association regulates the immunogenicity of microbial antigens.  CD291 is expressed in mice but no role for CD291 has been found in humans and it is speculated that other TLRs such as CD285 compensate for the lack of functional CD291.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD291 IN INTACT ANIMAL

In mice, CD291 recognizes E. coli and protects them from ascending urinary tract infections.  CD291 is activated by protozoan protect profilin and assists in protedction against T. gondii infection and other protozoans like Plasmodium sp.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD291: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD291: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrez239081
Antibodies

Revised June 25, 2008


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