|CD300c||CMRF35 family, CMRF35A, CMRF35A1, CMRF-34A, LIR|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|23 / 23|
|CD300c is expressed on large granular lymphocytes, monocytes, macrophages, on human granulocytes, dendritic cells and a proportion of peripheral bood lymphocytes. Expression is on neutrophils, NK cells, and 25% of circulating T cells and 15% of circulating B cells. |
CD300c antigen, which was identified by reactivity with a monoclonal antibody.
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.|
CD300c is a single-pass type-1 204 aa integral glycoprotein. It contains a 20 aa signal sequence, an 163 aa extracellular domain which contains a V-like Ig domain which is closely related to the 1st, 3rd and 4th IgSF domains of the poly-Ig receptor on epithelial cells, 2 potential N-linked glycosylation sites and an extended proline-rich membrane containing several serine and threonine amino acids which are potential O-glycosylated hinge-like sites, a hydrophobic transmembrane domain which has a glutamate residue, and a 19 aa short cytoplasmic domain. A Pro- and Ser-rich sequence that likely to be O-glycosylated forms a hinge-like region linking the V-set domain to the transmembrane sequence that contains a charged residue Glu that may enable the domain to associate with a molecule containing an ITIM thus conferring an activation function on CD300c. The presence of this charged residue suggests that the CD300c antigen may associate with other molecules in the membrane.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
CD300c has 2 potential N-linked glycosylation sites.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD300c: No information.|
Mitogenic stimulation of peripheral blood lymphocytes reduces both mRNA levels and cell surface expression of the CD300c antigen. The function of CD300c is under investigation but it is postulated to be an activating receptor.
Database accession numbers
Revised June 25, 2008