CD300c CMRF35 family, CMRF35A, CMRF35A1, CMRF-34A, LIR
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Dendritic Cell
Monocyte
Granulocyte
NK Cell
Neutrophil
Lymphocyte
Macrophage
Peripheral blood
23 / 23

Expression
CD300c is expressed on large granular lymphocytes, monocytes, macrophages, on human granulocytes, dendritic cells and a proportion of peripheral bood lymphocytes.  Expression is on neutrophils, NK cells, and 25% of circulating T cells and 15% of circulating B cells.  
CD300c antigen, which was identified by reactivity with a monoclonal antibody.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene family.

CD300c is a single-pass type-1 204 aa integral glycoprotein.  It contains a 20 aa signal sequence, an 163 aa extracellular domain which contains a V-like Ig domain which is closely related to the 1st, 3rd and 4th IgSF domains of the poly-Ig receptor on epithelial cells, 2 potential N-linked glycosylation sites and an extended proline-rich membrane containing several serine and threonine amino acids which are potential O-glycosylated hinge-like sites, a hydrophobic transmembrane domain which has a glutamate residue, and a 19 aa short cytoplasmic domain.  A Pro- and Ser-rich sequence that likely to be O-glycosylated forms a hinge-like region linking the V-set domain to the transmembrane sequence that contains a charged residue Glu that may enable the domain to associate with a molecule containing an ITIM thus conferring an activation function on CD300c.  The presence of this charged residue suggests that the CD300c antigen may associate with other molecules in the membrane.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

CD300c has 2 potential N-linked glycosylation sites.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD300c: No information.

Function

Mitogenic stimulation of peripheral blood lymphocytes reduces both mRNA levels and cell surface expression of the CD300c antigen.  The function of CD300c is under investigation but it is postulated to be an activating receptor. 

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD300c IN INTACT ANIMAL: No information.



Comments

MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD300c: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD300c: No information.

ADDITIONAL INSIGHTS

For further information see Green, B. J. et al (1998) Int.Immunol. 10: 891-899.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene10871Q08708
Antibodies

Revised June 25, 2008


Contact us: Webmaster |  509-335-9515 | Accessibility | Copyright | Policies
College of Veterinary Medicine Washington State University, Pullman, WA, 99164-7010 USA
Copyright 1995-2003 Washington State University