CD302 DCL1
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Granulocyte
Monocyte
Dendritic Cell
Macrophage
B Cell
Myeloid Cell
Reed-Sternberg Cell
Prothymocyte
Hodgkin lymphoma
30 / 30

Expression
CD302 is expressed on macrophages, granulocytes, monocytes and dendritic cells.  Expression is found on myeloid and B lymphoid cell lines.  Isoforms 2 and 3 are expressed in malignant Hodgkin's lymphoma cells called Hodgkin's and Reed Sternberg (HSR) cells.

Structure
MOLECULAR FAMILY NAME: Belongs to the C type lectin receptor family.

CD302 is a single-pass type-1 glycoprotein.  It contains an extracellular domain which contains a C-type lectin domain, a transmembrane domain and a cytoplasmic domain.  Information on structural features is limited at this time.  The structure is related to that of CD205 and genes for these molecules are close to each other on the same chromosome.  Reed-Sternberg cells of Hodgkin's lymphoma express a mRNA that is a fusion between CD205 and CD302.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 3 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD302: No information.

Function
CD302 is a C-type lectin that functions as an endocytic receptor for glycosylated antigens. 
Isoforms 2 and 3 are expressed in malignant Hodgkin's lymphoma cells with CD205 (DEC-205) called Hodgkin's and Reed Sternberg (HSR) cells.  Isoforms 2 and 3 are produced in HRS by a transcriptional control mechanism which co-transcribe an mRNA containing Ly75 and CD302 prior to generating the intergenically spliced mRNA to produce Ly75/CD302 fusion proteins.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD302 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD302: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD302: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 9936Q81X05
Antibodies

Revised June 25, 2008


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